Pirquinozol

Pirquinozol
Clinical data
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 2-(hydroxymethyl)pyrazolo[1,5-c]quinazolin-5(6H)-one;
CAS Number	65950-99-4;
PubChem CID	47783;
ChemSpider	11317704;
UNII	D16HG4V2UC;
KEGG	D05516;
CompTox Dashboard (EPA)	DTXSID00984432 ;
Chemical and physical data
Formula	C11H9N3O2
Molar mass	215.212 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OCc1cc2c3ccccc3NC(=O)n2n1;

Pirquinozol (SQ-13,847) is a drug which was investigated as an antiallergen and antiasthmatic agent in the early 1980s but was never marketed.^[1]^[2]^[3] Notably, pirquinozol is not an antihistamine, though it does block the release of histamine evoked by allergens, and it does not bind to β-adrenergic receptors either.^[1]

References[edit]

^ ^a ^b Free CA, Hall LE (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. II. Activity in vitro". The Journal of Pharmacology and Experimental Therapeutics. 213 (3): 437–40. PMID 6162946.
^ Casey FB, Abboa-Offei BE, Marretta J (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. I. Activity in vivo". The Journal of Pharmacology and Experimental Therapeutics. 213 (3): 432–6. PMID 7205610.
^ Casey FB, Abboa-Offei BE (June 1983). "Anti-allergic properties of pirquinozol (SQ 13,847) an orally effective agent. Evaluation in an anti-IgE-induced pulmonary function model in rats". The Journal of Pharmacy and Pharmacology. 35 (6): 394–6. doi:10.1111/j.2042-7158.1983.tb02967.x. PMID 6135784. S2CID 7790125.

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