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Oliver Wendell Holmes, Sr. (August 29, 1809 – October 7, 1894) was an American physician, professor, lecturer, and author. Regarded by his peers as one of the best writers of the 19th century, he is considered a member of the Fireside Poets. His most famous prose works are the "Breakfast-Table" series, which began with The Autocrat of the Breakfast-Table (1858). He is recognized as an important medical reformer.

Surrounded by Boston's literary elite—which included friends such as Ralph Waldo Emerson, Henry Wadsworth Longfellow, and James Russell Lowell—Holmes made an indelible imprint on the literary world of the 19th century. Many of his works were published in The Atlantic Monthly, a magazine that he named. For his literary achievements and other accomplishments, he was awarded numerous honorary degrees from universities around the world. Holmes's writing often commemorated his native Boston area, and much of it was meant to be humorous or conversational. Some of his medical writings, notably his 1843 essay regarding the contagiousness of puerperal fever, were considered innovative for their time. He was often called upon to issue occasional poetry, or poems written specifically for an event, including many occasions at Harvard. Holmes also popularized several terms, including "Boston Brahmin" and "anesthesia".