Prisca Liberali

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Prisca Liberali
Liberali presents at the Human Cell Atlas Computational Methods meeting in 2017
Born
Belgium
Alma materMario Negri Institute for Pharmacological Research
Sapienza University of Rome
Open University (PhD)
AwardsEMBO Gold Medal (2022)
EMBO Member (2022)
Scientific career
InstitutionsFriedrich Miescher Institute for Biomedical Research
ETH Zurich
University of Basel
ThesisMechanisms regulating the dual function of CtBP3/BARS in mammal cell membrane fission and transcription (2008)
Websiteliberalilab.org Edit this at Wikidata

Prisca Liberali is an Italian chemist who is a senior group leader at the Friedrich Miescher Institute for Biomedical Research.[1] Her research takes a systems biology approach to understand the behaviour of multi-cellular systems. She was awarded the EMBO Gold Medal and EMBO Membership in 2022.

Early life and education[edit]

Liberali was born in Belgium, and grew up between Belgium and Luxembourg.[2] Her parents worked for the European Union. She attended the Sapienza University of Rome, where she studied physical organic chemistry.[2] She moved to the Mario Negri Institute for Pharmacological Research, where she worked toward a doctorate in cell biology with Daniela Corda. Her doctorate looked at the mechanisms that regulate the function of the carboxy-terminal binding protein 3/brefeldin A-ribosylated substrate (CtBP3/BARS) in the membrane fission of mammal cells and was awarded by the Open University.[3] Her PhD used high-contrast screening and mapping of genetics interactions.[2]

Research and career[edit]

After her PhD, Liberali then worked as a postdoctoral fellow in the Institute of Molecular Systems Biology at ETH Zurich.[citation needed]

In 2015, Liberali was made an assistant professor at the University of Basel. She was simultaneously appointed a group leader at the Friedrich Miescher Institute for Biomedical Research, where she was made Senior Group Leader in 2021.[4]

Liberali makes use of a systems biology approach to understand tissue organisation.[5] She is interested in the collective properties of multi-cellular systems and how their properties arise from the behaviour of individual cells.[6] With this information, Liberali looks to understand cell reprogramming and disease.[7] Her early work considered intestinal organoids[8] and how they develop from stem cells.[9][10]

In June 2022, Liberali was awarded the EMBO Gold Medal by the European Molecular Biology Organization.[11] She was awarded EMBO Membership in 2022.[12]

Awards and honours[edit]

Selected publications[edit]

Her publications[1][5] include:

  • Population context determines cell-to-cell variability in endocytosis and virus infection[23]
  • Self-organization and symmetry breaking in intestinal organoid development[24]
  • The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS[25]

Personal life[edit]

Liberali is married with two children.[2] Her husband is Dutch and her children can speak five languages.[2] She has said that her guiding advice for someone about to start their own laboratory is "Sometimes good ideas need time, and the courage to just try them.".[2]

References[edit]

  1. ^ a b Prisca Liberali publications from Europe PubMed Central
  2. ^ a b c d e f "Cell scientist to watch – Prisca Liberali". Journal of Cell Science. 133 (10): jcs246272. 15 May 2020. doi:10.1242/jcs.246272. S2CID 219200956.
  3. ^ Liberali, Prisca (2008). Mechanisms regulating the dual function of CtBP3/BARS in mammal cell membrane fission and transcription (PhD thesis). Open University. OCLC 500299520. EThOS 446099 ProQuest 301737291.
  4. ^ FMI. "FMI - Friedrich Miescher Institute for Biomedical Research - Prisca Liberali". fmi.ch. Retrieved 2022-07-15.
  5. ^ a b Prisca Liberali publications indexed by Google Scholar Edit this at Wikidata
  6. ^ "Green light for 321 projects on self-chosen topics". Swiss National Science Foundation (SNSF) (in German). Retrieved 2022-07-15.
  7. ^ FMI. "FMI - Friedrich Miescher Institute for Biomedical Research - Prisca Liberali". fmi.ch. Retrieved 2022-07-15.
  8. ^ "Leaders of the Field Discuss Advances in Organoid Applications". stemcell.com. Retrieved 2022-07-15.
  9. ^ "Don't be afraid, be bold - Interview with Prisca Liberali". Life Innovation Blog. 2021-02-11. Retrieved 2022-07-15.
  10. ^ Lukonin, Ilya; Zinner, Marietta; Liberali, Prisca (October 2021). "Organoids in image-based phenotypic chemical screens". Experimental & Molecular Medicine. 53 (10): 1495–1502. doi:10.1038/s12276-021-00641-8. PMC 8569209. PMID 34663938.
  11. ^ "Prisca is awarded the EMBO Gold Medal!". The Liberali Lab. 24 June 2022. Retrieved 2022-07-15.
  12. ^ "EMBO elects 67 new members and associate members – Press releases – EMBO". 2022-07-06. Retrieved 2022-07-15.
  13. ^ FMI. "FMI - Friedrich Miescher Institute for Biomedical Research - Prisca Liberali". fmi.ch. Retrieved 2022-07-15.
  14. ^ "Liberali | Basel Stem Cell Network". baselstemcells.ch. Retrieved 2022-07-15.
  15. ^ "Prof. Prisca Liberali - AcademiaNet". academia-net.org. Retrieved 2022-07-15.
  16. ^ "ERC FUNDED PROJECTS".
  17. ^ "Prisca becomes an EMBO Young Investigator". The Liberali Lab. 18 November 2019. Retrieved 2022-07-15.
  18. ^ FMI. "Prisca Liberali becomes an EMBO Young Investigator". fmi.ch. Retrieved 2022-07-15.
  19. ^ "Prisca Liberali awarded Friedrich Miescher Award". unibas.ch. Retrieved 2022-07-15.
  20. ^ "Prisca Liberali awarded EMBO Gold Medal 2022 – Press releases – EMBO". 2022-06-24. Retrieved 2022-07-15.
  21. ^ "Prisca Liberali awarded EMBO Gold Medal 2022". unibas.ch. Retrieved 2022-07-15.
  22. ^ Seeing is believing: Meet Prisca Liberali, retrieved 2022-07-15
  23. ^ Berend Snijder; Raphael Sacher; Pauli Rämö; Eva-Maria Damm; Prisca Liberali; Lucas Pelkmans (26 August 2009). "Population context determines cell-to-cell variability in endocytosis and virus infection". Nature. 461 (7263): 520–523. doi:10.1038/NATURE08282. ISSN 1476-4687. PMID 19710653. Wikidata Q39807636.
  24. ^ Denise Serra; Urs Mayr; Andrea Boni; et al. (24 April 2019). "Self-organization and symmetry breaking in intestinal organoid development". Nature. 569 (7754): 66–72. doi:10.1038/S41586-019-1146-Y. ISSN 1476-4687. PMC 6544541. PMID 31019299. Wikidata Q90284285.
  25. ^ Prisca Liberali; Elina Kakkonen; Gabriele Turacchio; et al. (20 March 2008). "The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS". The EMBO Journal. 27 (7): 970–981. doi:10.1038/EMBOJ.2008.59. ISSN 0261-4189. PMC 2323256. PMID 18354494. Wikidata Q30481720.
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