RS1

RS1 or RS-1 may refer to:

• ALCO RS-1, a 4-axle diesel-electric locomotive built by Alco-GE and later by Alco alone
• K-5 (missile), also known as RS-1U or product ShM, an early Soviet air-to-air missile
• The Reid and Sigrist R.S.1, a British twin-engined, three-seat advanced trainer developed during World War II
• Retinoschisin, a protein that in humans is encoded by the RS1 gene
• Ross RS-1 Zanonia, a single seat, gull-winged glider
• RS-1, an Indian satellite in the Rohini (satellite) series
• (7080) 1986 RS1, generally written as (7080) 1986 RS₁, a main-belt minor planet
• Sikorsky S-41, an amphibious flying boat airliner designated by the U.S. Navy as RS-1
• Stadler Regio-Shuttle RS1, a diesel railcar manufactured by Stadler Rail AG
• Goodyear RS-1 America's first semi-rigid airship
• RS/1, statistical software from Bolt, Beranek and Newman
• The first Randall–Sundrum model
• ABL Space Systems RS1, a planned liquid-fuelled small-lift launch vehicle
• RS1, a type of resistant starch