Ronald Duman
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Ronald Duman | |
|---|---|
| Born | Ronald Stanton Duman February 6, 1954 Ebensburg, Pennsylvania, U.S. |
| Died | February 1, 2020 (aged 65) Guilford, Connecticut, U.S. |
| Alma mater | College of William & Mary University of Texas Health Science Center at Houston |
| Occupation | Neuroscientist |
Ronald Stanton Duman (February 6, 1954 – February 1, 2020)[1] was a Professor of Psychiatry and Pharmacology Director, Division of Molecular Psychiatry and Abraham Ribicoff Research Facilities at Yale University.[2]
Education[edit]
Duman graduated from the College of William & Mary (where he played varsity football as a middle linebacker) in 1976. He received his Ph.D. from the University of Texas Health Science Center at Houston (UTHealth) in 1985.
Career[edit]
Ron Duman's research centered around the biological mechanisms behind antidepressants. In his landmark 1995 paper, he discovered that antidepressants increase the gene expression of Brain-Derived Neurotrophic Factor, or (BDNF)[3] in the hippocampus. In a later paper he discovered that the downstream effect of BDNF is to increase neurogenesis or the formation of new neurons in the dentate gyrus of the hippocampus.[4]
The results of this work led him to formulate the hypothesis that depression is caused by a decrease in hippocampal neurogenesis caused by elevated cortisol levels.
Death[edit]
Ronald Duman died on February 1, 2020, at the age of 65 while hiking in Guilford, Connecticut.[5]
Notes[edit]
- ^ "Ronald Stanton Duman, PhD (Obituary)". The Tribune-Democrat. February 6, 2020. Retrieved February 8, 2020.
- ^ Duman's Yale Faculty Website Archived 3 June 2009 at the Wayback Machine
- ^ Pramanick, D.; Forstová, J.; Pivec, L. (1976). "First paper demonstrating the link between antidepressants and BDNF levels". FEBS Letters. 62 (1): 81–84. doi:10.1016/0014-5793(76)80021-x. PMID 2505. S2CID 20044419. Archived from the original on 22 June 2022. Retrieved 11 September 2017.
- ^ Abstract of paper demonstrating that antidepressants increase neurogenesis Archived 10 June 2022 at the Wayback Machine
- ^ Ronald S. Duman, PhD, Pioneering Neuroscientist of Stress, Depression, and Antidepressant Treatment Dies at 65
| International | |
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| National | |
| Academics | |
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- 1954 births
- 2020 deaths
- American neuroscientists
- American psychiatrists
- People from Ebensburg, Pennsylvania
- Scientists from Pennsylvania
- University of Texas Health Science Center at Houston alumni
- William & Mary Tribe football players
- Yale School of Medicine faculty
- Members of the National Academy of Medicine
- American psychiatrist stubs