Small nucleolar RNA SNORA30
| Small nucleolar RNA SNORA30/SNORA37 family | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA30 | |
| Identifiers | |
| Symbol | SNORA30 |
| Alt. Symbols | snoACA30 |
| Rfam | RF00415 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; H/ACA-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000594 |
| PDB structures | PDBe |
In molecular biology, SNORA30 (also known as ACA30) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of eukaryotic cells. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA' as it 'guides' the modification process.
ACA30 was originally cloned from HeLa cells[1] and belongs to the H/ACA box class of snoRNAs based on its structure and the proteins it is associated with. snoRNA ACA30 is predicted to guide the pseudouridylation of U4643 of 28S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine(Ψ).
This snoRNA is related to other snoRNAs identified in human (ACA37)[1] and mouse (MBI-26).[2]
References[edit]
- ^ a b Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
- ^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
External links[edit]
- Page for Small nucleolar RNA SNORA30 at Rfam
- Entry for SNORA30 at snoRNABase
- Entry for SNORA37 at snoRNABase
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