Talk:Daidzein
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Phytoestrogens[edit]
I added an internal link to phytoestrogens. This may avoid having to duplicate referrences for biologic effect. Maybe this article shoul concentrate on the chemical aspects?Pustelnik 02:25, 14 October 2007 (UTC)
Define acronyms and specialty jargon plz[edit]
Directly from the article:
- Activation of PPARs
What are PPARs? Should be spelled out in full the first time it's used, with the acronym following in parentheses. After that's done once, using the acronym is fine.
- Isoflavone daidzein transactivates all three PPAR[clarification needed] isoforms, α, δ, and γ and influences target cells.[4]
"Influencing target cells" is almost meaningless. Influences them how? In vitro or in vivo?
- Similar to another isoflavone genistein,[5] daidzein at concentrations between 1 and 100 uM activates PPARs in a dose dependent way in KS483 mesenchymal progenitor cells, breast cancer MCF-7 cells, T47D cells and MDA-MD-231 cells.
This almost has to be in vitro cell culture work, right? Then say so please.
- Studies have shown that both ERs and PPARs influence each other and therefore induce differential effects in a dose-dependent way. The final biological effects of daidzein are determined by the balance among these pleiotrophic actions.[4][6]
What effects are being referred to here? What are ERs? (Same acronym issue as with PPARs.) What "pleiotrophic" actions?
I have a Ph.D. in nutrition from the University of Minnesota, and during my grad school and postdoc years, soy isoflavones were all the rage among nutrition researchers, though I focused on appetite & memory (neuroscience). With a background and education like mine, why am I unable to read this article? Was it written by biochemists or molecular biologists for the exclusive use of their peers? That's what journals are for, though of course journals also require authors to define their acronyms and specialized terms up front. It's not difficult to write this kind of article for a broader audience, which is Wikipedia's readership.Dcs002 (talk) 22:36, 6 August 2012 (UTC)