Talk:Dissolution testing
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 | The contents of the USP Dissolution Apparatus 2 page were merged into Dissolution testing on 02/15/2017. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
What does dissolution mean?[edit]
I think it would make the article clearer if "dissolution" was explained. CBHA (talk) 03:22, 10 May 2013 (UTC)
@CBHA: A good suggestion but I disagree. Dissolution testing is a common name used in the Pharma industry, it should be pretty self-evident to most readers what dissolution means even if your not sure or don't work in that field ( a simple Google search can rectify any doubts). For those who didn't know dissolution means essentially breaking down a tablet or solid dosage by placing it in dissolution medium (which can range from degassed or sonicated deionized water to some chemically prepared solution), heating that dissolution medium up and having a paddle or basket rotate the dissolution medium for a predetermined amount of time (the amount of time depends on the protocol for that drug) in order to collect a sample. --Have a great day :) , Sanjev Rajaram (talk) 22:32, 11 February 2017 (UTC)
Merger and expand Proposal[edit]
I propose that USP Dissolution Apparatus 2 be merged into Dissolution testing. I think that the content in the article can easily be explained in the context of Dissolution testing, and the article is of a reasonable size that the merging of will not cause any problems as far as article size or undue weight is concerned. Also I think we should expand to include the specifics of the other dissolution appratuses Have a great day :) , Sanjev Rajaram (talk) 01:37, 12 February 2017 (UTC)
- Support. Sounds very suitable to me. USP Dissolution Apparatus 2 isn't independently notable, and will benefit from the context of the broader topic here. Klbrain (talk) 22:45, 12 February 2017 (UTC)
Excellent. I doubt anyone has objections to this so I'm going to be bold and merge the article. If anyone disagrees you can unmerge the article and discuss the reasons here. --Have a great day , Sanjev Rajaram (talk) 02:48, 15 February 2017 (UTC)
Analysis of dissolution samples[edit]
Hi all, Sorry to intrude. I think it's not stressed that hplc is not an identification method,only the separation. It very much depends on the detector which in both cases i think the author ment is the same. So for most of dissolution tested drugs it's for uv analysis. I propose to make the line for most drugs tested by diss method undergo uv/vis analysis either by the stand alone spectrophotometer or the hplc equipped with the suitable detector No harm meant,hope i helped Michael M. Meistelman (talk) 07:42, 9 May 2017 (UTC)
@Meistelman: Don't worry the talk page is meant for discussion on this topic you're not intruding at all. As far as I'm aware both HPLC and UV testing are used to analyze samples from dissolution testing. The method is dependent on what's being tested some drugs will use the HPLC others will use the UV. If you could provide a source to back up that statement then it could be included in the article. --Have a great day , Sanjev Rajaram (talk) 19:38, 9 May 2017 (UTC)
Update* After reading the USP guidelines and reviewing HPLC testing I've concluded that the addition is not necessary as HPLC testing already implies that UV will be used after separation when producing the monograph. Thank you bringing up this discussion. --Have a great day , Sanjev Rajaram (talk) 20:34, 9 May 2017 (UTC)