Talk:Epibatidine

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It is important to remember that in 1970, Mr. John Daly came to Ecuador and illegally took 750 frogs. His research is of course valuable, but he never has stated that the indigenous people have used the frog since ancient times, and that they never received any compensation for the use of their traditional knowledge. —Preceding unsigned comment added by 200.107.50.243 (talk) 17:17, August 26, 2007 (UTC)

I'm in the process of making some rather large changes to this article. However, I don't have a whole lot of knowledge of chemistry so could someone complete the chemistry box? maybe add a section. I deleted more than half of the article because it was plagiarized word for word from www.mahalo.com/epibatidine --SlimNm (talk) 20:10, 24 December 2010 (UTC)[reply]

Hi, we're a group of young toxicologists working on a project for the Radboud University of Nijmegen. We've done literature research on epibatidine and would like to improve this article in the next few days. I'm afraid that we're no experts on wikipedia, but we'll do our best to improve it as best as we can. We'll have to delete some of the existing information on the page to make our information coherent, but we'll keep it to a minimum. Feedback is welcome, of course. -- TheToxicologists (talk) 16:47, 3 April 2011 (UTC)[reply]

The changes have been made. As said before, feedback is welcome. We did our best to mimic the wikipedia code. Hope it worked out! We also tried to upload images to support and clarify our text (and also making it more lively), but encountered the licensing problem. Is it still a possibility to do so? We hope our changes will be respected in this way.TheToxicologists (talk) 18:02, 6 April 2011 (UTC)[reply]

We are currently editing the page by adding some pictures. We hope that sufficient licensing has been provided. Sincerely, TheToxicologists (talk) 21:14, 6 April 2011 (UTC)[reply]

Synthesis Image[edit]

Image clearly NOT of last 2 steps. Those are the key steps, but not the final ones. — Preceding unsigned comment added by 213.106.56.145 (talk) 11:44, 27 June 2013 (UTC)[reply]

Merge with curare?[edit]

Epibatidine is the same thing as curare. — Preceding unsigned comment added by 5.241.17.169 (talk) 07:39, 20 April 2014 (UTC)[reply]

Curare is not a single molecule, it's typically a plant extract and can contain many compounds. In some types of curare, epibatidine is the active compound, but in some types it may not be present at all.Ajfrontier (talk) 18:27, 3 May 2015 (UTC)[reply]
Look up tubocurarine chloride, which is extracted from the bark of Chondrodendron species and was used therapeutically for a long time. It has a completely different chemical structure. Prakash Nadkarni (talk) 16:34, 22 September 2017 (UTC)[reply]

External links modified[edit]

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Corrected some major errors in the "Mechanism of Action" section[edit]

This section had two major errors:

1. It claimed a major "therapeutic advantage" of epibatidine over morphine in that it did not cause tolerance. This point is moot, since epibatidine is not used clinically, after studies in rodents showed lethality even in very small doses.

2. It claimed (twice) that paralysis was due to action on muscarinic acetylcholine receptors, putting in a lot of irrelevant detail about muscarinic receptor subtypes. Nicotinic receptors, NOT muscarinic receptors, are present at the skeletal neuromuscular junction. Nicotinic antagonists are used clinically to induce paralysis during certain major surgeries (the patient must be kept alive by artificial ventilation during the paralysis). Also, atropine, the most abundant alkaloid in the poisonous Belladonna plant and the classical muscarinic antagonist, does not cause skeletal muscle paralysis in toxic doses: the victim becomes psychotic and delirious, and thrashes about.

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