Talk:Gramine
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unsourced[edit]
moved here per PRESERVE
- Uses
Gramine is used mostly in synthetic organic chemistry as a starting material for tryptophan syntheses.
All reactions of gramine follow the same general reaction scheme. Gramine is reacted with a strong electrophile, such as methyl iodide, to form the quaternary ammonium salt 2. The ammonium salt will undergo a Hofmann elimination or Michael addition to give the very active intermediate 3, which can accept a wide range of nucleophiles to give the desired product 4.
It did say that gramine has use in the synthesis of Bucindolol as well as laboratory man-made Indole-3-carbinol oligomers.