Talk:Gut–brain axis

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Text and/or other creative content from this version of Gut flora was copied or moved into Gut–brain axis with this edit on 20 June 2016. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted as long as the latter page exists.

Text and/or other creative content from this version of Psychobiotic was copied or moved into Gut–brain axis with this edit on 20 June 2016. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted as long as the latter page exists.

Text and/or other creative content from this version of Enteric nervous system was copied or moved into Gut–brain axis with this edit on 20 June 2016. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted as long as the latter page exists.

Text and/or other creative content from this version of Human microbiota was copied or moved into Gut–brain axis with this edit on 20 June 2016. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted as long as the latter page exists.

Wiki Education Foundation-supported course assignment[edit]

This article was the subject of a Wiki Education Foundation-supported course assignment, between 16 August 2021 and 19 November 2021. Further details are available on the course page. Student editor(s): Thinkpins.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 22:03, 17 January 2022 (UTC)[reply]

Good online source[edit]

I'm not an expert so I won't work on this article, but here is a good online source for anyone reviewing this new article: http://medicalxpress.com/news/2013-11-uncovers-gut-brain-axis.html Rgrds. --64.85.216.192 (talk) 07:14, 2 December 2013 (UTC)[reply]

Copyvio[edit]

It appears that much of this article was taken from this source. I have redacted for now, needs to be completely reworded to comply with our copyvio policy. Yobol (talk) 16:44, 10 December 2013 (UTC)[reply]

I have concerns that the remainder of the article also is a copyvio based on the grammar and syntax, but do not have access to cited article (Chen 2013) to compare. Yobol (talk) 17:00, 10 December 2013 (UTC)[reply]

which animals were exposed? -- unclear sentence[edit]

From the article: These studies used germ free animals compared to normal animals, which were later exposed to pathogenic bacterial infections, probiotic bacteria and antibiotic drugs. Here's my question: Which animals were exposed... the normal animals or the germ free animals? Did all of the studies include both germ free animals and normal animals? Were they always in comparison to one another. Since we're talking about multiple studies, I suspect the answer depends, in each case, on the specific study we're talking about. I like that the sentence is trying to talk about the sort of techniques used to elucidate the cognitive impacting attributes of the microbiome, but I don't like that the sentence isn't especially clear. Any suggestions for making it workable? Snazzywiki (talk) 03:53, 29 November 2015 (UTC)[reply]

Started working this over tonight[edit]

Am going to bed now. This article was (and still is) really heavy handed with one-way effects of the gut flora on mental/neuro health. It is a two-way street; there was also no discussion here about the endogenous gut-brain axis and i have started to incorporate that. Long ways to go... Jytdog (talk) 06:59, 20 June 2016 (UTC)[reply]

Recent changes - no need to fuss over the mouse and primary sources, all that stuff is going to be worked over. I didn't get back here today, got caught up in RL and another article. Will be back tomorow! Jytdog (talk) 05:10, 21 June 2016 (UTC)[reply]

done enough for now. took the construction tag off. the article needs more development of the endogenous gut-brain axis. i reeled back the over-certainty of the the role of gut flora and the dramatic overcertainty of probiotics in CNS conditions. Jytdog (talk) 07:19, 25 June 2016 (UTC)[reply]

Review articles from the deleted "Further reading" section[edit]

The further reading section was deleted; since it contained two review articles, I'm moving them here since they could be cited in the article later. Seppi333 (Insert 2¢) 23:15, 15 October 2017 (UTC)[reply]

Hooper LV; Macpherson AJ (Mar 2010). "Immune adaptations that maintain homeostasis with the intestinal microbiota". Nat Rev Immunol. 10: 159–69. doi:10.1038/nri2710. PMID 20182457..
De Palma, G; Collins, SM; Bercik, P (2014). "The microbiota-gut-brain axis in functional gastrointestinal disorders". Gut Microbes. 5: 419–29. doi:10.4161/gmic.29417. PMC 4153782. PMID 24921926.

Merger proposal[edit]

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.

To merge Neurogastroenterology to Enteric nervous system as a more suitable target. Klbrain (talk) 07:54, 28 October 2019 (UTC)[reply]

I propose that Neurogastroenterology be merged here, into Gut–brain axis. This is the broader concept, and the content there would easily fit here and should be here. Jytdog (talk) 16:18, 12 August 2018 (UTC)[reply]

Support. Content of Neurogastroenterology has been underedited over recent years and is readily integrated into the better-referenced and more frequently edited Gut-brain axis article. --Zefr (talk) 16:59, 12 August 2018 (UTC)[reply]

That scope of that term pertains more to the enteric nervous system than the gut-brain axis. Seppi333 (Insert 2¢) 19:27, 12 August 2018 (UTC)[reply]

that would work as a merge target as well Jytdog (talk) 19:38, 12 August 2018 (UTC)[reply]

I support making Enteric nervous system the target of the redirect from Neurogastroenterology, and merging the content to either that page or to here. In other words, merge enteric-related content there, and if there is any gut-brain content, merge that here. --Tryptofish (talk) 20:59, 12 August 2018 (UTC)[reply]
I'm in support of what Tryptofish proposes. It's more categorical and will neaten things up nicely. Rap Chart Mike (talk) 12:29, 15 August 2018 (UTC)[reply]
Support Tryptofish's proposal --Tom (LT) (talk) 23:14, 15 August 2018 (UTC)[reply]
Support - This entry is an included concept of neurogastroenterology, and would fit well therein... Veryproicelandic (talk) 05:40, 16 July 2019 (UTC)[reply]

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Gut-Brain axis major edits[edit]

I made some major edits to this page that were rightfully undone. I would like to try again and have time to work on the page if anyone would like to point out some of the mistakes I made. I'm happy to make corrections! Thank you.

This is what I had in mind for an introduction.

The gut-brain axis is a complex neural and biochemical information/signal network that facilitates communication between various parts of the central nervous system and enteric nervous system. To facilitate communication this bidirectional axis comprises various components of the immune system, endocrine system, nervous system and host microbiota interactions; whereby signals are transmitted from the brain to the gut and from the gut to the brain. Dysfunction of the gut-brain axis has been linked to numerous disorders of the nervous system and gastrointestinal(GI) tract[2]. These disorders are known to manifest in a variety of different ways, including emotional and/or cognitive disturbances including autism[3], anxiety[4] and depression[4] as well as GI problems[5][6], such as irritable bowel syndrome. Gut-microbiome interactions are thought to be a key component of many gut-brain axis related disorders and it’s thought that future therapeutic initiatives may be targeted at manipulating the gut-brain-microbiota axis.[2] Thinkpins (talk) 00:14, 17 November 2021 (UTC)[reply]

Commented on Thinkpins' talk page. The first two sentences in italics above are not an improvement over what the article states now. The content beginning Dysfunction... is speculation based on weak sources. See WP:MEDHOW, Importance of sources. MEDHOW states: "Wikipedia is an encyclopedia of notable topics written for a general audience. It is neither a research paper nor a how-to manual; we summarize accepted knowledge here, and we find "accepted knowledge" in literature reviews published in good journals or in clinical guidelines or statements by major medical/scientific bodies."

This PubMed search for "gut-brain axis" linked with "meta-analysis" shows publications that were inconclusive, in dubious, weak publications (alternative medicine) or just speculation on possible effects or causes. A PubMed search for systematic reviews produced this result. A 2021 systematic review on the gut-brain axis association with anxiety or depression was inconclusive. New content should be based on high-quality reviews published within the past 5 years. Zefr (talk) 18:50, 17 November 2021 (UTC)[reply]

"Gut flora" versus "gut microbiota"[edit]

I would like to start a discussion about potentially using "gut microbiota" in the place of "gut flora," which has been used several times throughout the article (45 times as "gut flora" and 18 times for "gut microbiota"). It is my understanding that using "gut flora" to describe gut microbiota is considered somewhat outdated given that it technically refers to plants. Additionally, the link to "gut flora" in the first paragraph of the "Gut flora" section refers one to the article titled "Gut microbiota." While "gut flora" may be more recognizable to a lay audience, I would like to hear others' input on whether or not changing "gut flora" to "gut microbiota" would be more appropriate. Thomas K. Duncan (talk) 00:25, 18 November 2021 (UTC)[reply]

"Gut microbiota" (vs. "flora") has become the more common term in the last decade, as indicated in this PubMed search. Zefr (talk) 01:16, 18 November 2021 (UTC)[reply]

Dopamine signalling during exercise & motivation[edit]

Please include info on this here and possibly elsewhere once a review covers the study/finding:

Researchers report the discovery of a gut–brain connection in mice that contributes to motivation for exercise and can enhance performance by augmenting dopamine signalling during physical activity.^[1]^[2]

I don't know how long it would take until there is a review, you could check if such exists if this post is reasonably old.

References

^ "Your gut bacteria may influence how motivated you are to exercise". New Scientist. Retrieved 17 January 2023.
^ Dohnalová, Lenka; Lundgren, Patrick; Carty, Jamie R. E.; Goldstein, Nitsan; Wenski, Sebastian L.; Nanudorn, Pakjira; Thiengmag, Sirinthra; Huang, Kuei-Pin; Litichevskiy, Lev; Descamps, Hélène C.; Chellappa, Karthikeyani; Glassman, Ana; Kessler, Susanne; Kim, Jihee; Cox, Timothy O.; Dmitrieva-Posocco, Oxana; Wong, Andrea C.; Allman, Erik L.; Ghosh, Soumita; Sharma, Nitika; Sengupta, Kasturi; Cornes, Belinda; Dean, Nitai; Churchill, Gary A.; Khurana, Tejvir S.; Sellmyer, Mark A.; FitzGerald, Garret A.; Patterson, Andrew D.; Baur, Joseph A.; Alhadeff, Amber L.; Helfrich, Eric J. N.; Levy, Maayan; Betley, J. Nicholas; Thaiss, Christoph A. (December 2022). "A microbiome-dependent gut–brain pathway regulates motivation for exercise". Nature. 612 (7941): 739–747. Bibcode:2022Natur.612..739D. doi:10.1038/s41586-022-05525-z. ISSN 1476-4687. PMID 36517598. S2CID 254729201.

Prototyperspective (talk) 21:46, 3 February 2023 (UTC)[reply]

Wiki Education assignment: The Microbiology of College Life[edit]

This article is currently the subject of a Wiki Education Foundation-supported course assignment, between 22 January 2024 and 6 May 2024. Further details are available on the course page. Student editor(s): Gs742, Melissareifman, Lydiawang1 (article contribs).

— Assignment last updated by Gs742 (talk) 01:38, 18 March 2024 (UTC)[reply]

[1] "Your gut bacteria may influence how motivated you are to exercise". New Scientist. Retrieved 17 January 2023.

[2] Dohnalová, Lenka; Lundgren, Patrick; Carty, Jamie R. E.; Goldstein, Nitsan; Wenski, Sebastian L.; Nanudorn, Pakjira; Thiengmag, Sirinthra; Huang, Kuei-Pin; Litichevskiy, Lev; Descamps, Hélène C.; Chellappa, Karthikeyani; Glassman, Ana; Kessler, Susanne; Kim, Jihee; Cox, Timothy O.; Dmitrieva-Posocco, Oxana; Wong, Andrea C.; Allman, Erik L.; Ghosh, Soumita; Sharma, Nitika; Sengupta, Kasturi; Cornes, Belinda; Dean, Nitai; Churchill, Gary A.; Khurana, Tejvir S.; Sellmyer, Mark A.; FitzGerald, Garret A.; Patterson, Andrew D.; Baur, Joseph A.; Alhadeff, Amber L.; Helfrich, Eric J. N.; Levy, Maayan; Betley, J. Nicholas; Thaiss, Christoph A. (December 2022). "A microbiome-dependent gut–brain pathway regulates motivation for exercise". Nature. 612 (7941): 739–747. Bibcode:2022Natur.612..739D. doi:10.1038/s41586-022-05525-z. ISSN 1476-4687. PMID 36517598. S2CID 254729201.

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