Talk:Helix-turn-helix

A fact from Helix-turn-helix appeared on Wikipedia's Main Page in the Did you know column on 21 October 2004. The text of the entry was as follows:

Did you know... that the helix-turn-helix structural motif is found in many proteins that regulate gene expression?

A record of the entry may be seen at Wikipedia:Recent additions/2004/October.

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Molecular Biology: Genetics / MCB

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bHLH[edit]

A certain receptor, AhR (aryl hydrocarbon receptor) and other transcription factors have, according to my sources, "a basic helix-loop-helix motif". I'd like to know if basic in this context means "elementary, simple, merely functional" or alkaline, the opposite of acidic. -Samulili 20:01, 9 May 2006 (UTC)[reply]

the latter - it's a frequent feature of DNA binding motif nomenclature, for example in the bZIP domain of the Leucine zipper DNA binding motif, the DNA binding region comprises a number of basic aminoacids such as arginine and lysine. Philbradley 14:21, 9 December 2006 (UTC)[reply]

Merger proposal[edit]

I think Winged helix turn helix should be merged with this page, to go in a separate section. This is one of many variants of the helix turn helix domain which is likely to have arisen from a single ancestor (see PMID:15808743) and this article should be expanded to encompass these. --RE73 (talk) 11:47, 25 October 2011 (UTC)[reply]

Agree Alexbateman (talk) 13:44, 25 October 2011 (UTC)[reply]

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