Talk:Immunostimulant

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06.35,25th Oct.,2005

NO LIST[edit]

Where is the list of Immunostimulators? No one is listed! —Preceding unsigned comment added by 62.80.190.82 (talk) 15:10, 26 May 2008 (UTC)[reply]

immulastimulators[edit]

Immunostimulators are the drugs which can stimulate the immune system by inducing activation or increasing activity of any of it's components.

WikiProject class rating[edit]

This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 16:28, 10 November 2007 (UTC)[reply]

Requested move[edit]

The following discussion is an archived discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. No further edits should be made to this section.

The result of the move request was Done. Discussion both opened and listed at Wikipedia:Requested moves for at least 5 days with no objections against the move. — Aitias // discussion 00:34, 26 February 2009 (UTC)[reply]

"Immunostimulant" is the name used by ATC (see ATC code L03, [1]). It is also the far more common name (as per Google: 8,900 vs 90,500). --ἀνυπόδητος (talk) 16:31, 21 February 2009 (UTC)[reply]

Neutral there's no clear per WP:UCN winner. I find 134,000 Google hits for Immunostimulator, verses 114,000 for the target (is it possible you misspelled Immunostimulator in your search when you found only 8,900?). Similarly, on the more reliable sources front, Google books returns 1,090 for present name verses 990 for target. Similar results are found using Google scholar (15,000ish verses 16,000ish in favor of present name). So, on all three, the present name edges out the target as to commonality. However, a news search does return about twice the results for the target; 350 verses 650. I have no position because I am ignorant of the weight that should be given to listing in ATC codes cited by the nominator, but I though I would share the results of my commonality search--Fuhghettaboutit (talk) 00:36, 26 February 2009 (UTC)[reply]

The above discussion is preserved as an archive of a requested move. Please do not modify it. Subsequent comments should be made in a new section on this talk page. No further edits should be made to this section.

Please update with: info on types/mechanisms/categories of immunostimulants/immune-training[edit]

I think it would be good to expand the article with info about the immunostimulants in use and under research, in particular which categories and mechanisms are known to exist, especially those within "Specific immunostimulants" (and types of vaccines could also be listed). This could be a list or a table. The different types could be get distinguished/compared there and each category of immunostimulants could list the diseases it is applied (or developed) for.

Moreover, the article never uses/explains the related term "Immune training".

I think the article should then also contain a wikilink to OM-85 and short info on the study "Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies". It's currently featured in 2022 in science like so:

A study shows how immune training via a mix of molecules extracted from certain bacteria could potentially protect infants against pervasive severe lower respiratory tract infections.^[1]^[2]

The most relevant of the study text seems to be (this could also be used to improve the article OM-85):

[Immune training (IT)] involves stimulation of long-lasting augmented innate immune function after controlled exposure to microbe-derived stimuli, manifesting in enhanced resistance to pathogens unrelated to the original stimulus. Maintenance of this broad-spectrum “innate immune memory” state appears to involve both epigenetic mechanisms and changes in the phenotypes/population size of key myeloid precursors. The neonatal and infant periods appear to represent life phases during which the immune system is particularly susceptible to microbe-associated IT effects.
Opportunities for clinical studies evaluating this concept and elucidating underlying mechanisms are currently limited as a result of the restricted range of IT treatment agents with proven safety in this age group. The present study focuses on one such available agent, OM85, which comprises a polybacterial extract from a mixture of respiratory pathogens that have been in clinical use since the 1980s.

References

^ Troy, Niamh. "OM85 appears to boost babies' immune systems and protects them from serious lung infections". medicalxpress.com. Retrieved 16 March 2022.
^ Troy, Niamh M.; Strickland, Deborah; Serralha, Michael; Jong, Emma de; Jones, Anya C.; Read, James; Galbraith, Sally; Islam, Zahir; Kaur, Parwinder; Mincham, Kyle T.; Holt, Barbara J.; Sly, Peter D.; Bosco, Anthony; Holt, Patrick G. (14 February 2022). "Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies". Journal of Allergy and Clinical Immunology. 0 (0). doi:10.1016/j.jaci.2022.01.001. ISSN 0091-6749.

Prototyperspective (talk) 20:35, 23 March 2022 (UTC)[reply]

[1] Troy, Niamh. "OM85 appears to boost babies' immune systems and protects them from serious lung infections". medicalxpress.com. Retrieved 16 March 2022.

[2] Troy, Niamh M.; Strickland, Deborah; Serralha, Michael; Jong, Emma de; Jones, Anya C.; Read, James; Galbraith, Sally; Islam, Zahir; Kaur, Parwinder; Mincham, Kyle T.; Holt, Barbara J.; Sly, Peter D.; Bosco, Anthony; Holt, Patrick G. (14 February 2022). "Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies". Journal of Allergy and Clinical Immunology. 0 (0). doi:10.1016/j.jaci.2022.01.001. ISSN 0091-6749.

[1]

[2]