Talk:Peroxisome proliferator-activated receptor

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human ppar-delta activation[edit]

where can i get ppar-delta activating medicaments? —The preceding unsigned comment was added by 84.61.15.154 (talk) 12:50, 31 March 2007 (UTC).[reply]

What would you like to achieve with that? JFW | T@lk 21:23, 27 November 2007 (UTC)[reply]

Muraglitazar[edit]

We should perhaps quote Steven Nissen's destruction of muraglitazar as an antidiabetic. Obviously, we still know too little about PPAR to predict firmly what modulation will do to bone and coronary artery. JFW | T@lk 21:23, 27 November 2007 (UTC)[reply]

RE: Muraglitazar: I presume you mean this? Nissen SE, Wolski K, Topol EJ (2005). "Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus". JAMA. 294 (20): 2581–6. doi:10.1001/jama.294.20.joc50147. PMID 16239637.{{cite journal}}: CS1 maint: multiple names: authors list (link) Boghog2 (talk) 21:47, 27 November 2007 (UTC)[reply]

RE: PPAR modulators effect on bone: this looks sobering: Takada I, Suzawa M, Matsumoto K, Kato S (2007). "Suppression of PPAR-γ transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts". Ann N Y Acad Sci. doi:10.1196/annals.1402.034. PMID 17656564.{{cite journal}}: CS1 maint: multiple names: authors list (link) Boghog2 (talk) 21:47, 27 November 2007 (UTC)[reply]

PPAR/plant sterols/and natural alternatives?[edit]

I have a couple of questions I hope someone here can help me answer. First, seeing as plant sterols can also reduce cholesterol and I beleive, increase the HDL, does it have any impact on PPAR's? Also, are there any known natural or herbal alternatives that also activate PPAR? —Preceding unsigned comment added by Interestedperson (talk • contribs) 05:07, 4 January 2009 (UTC)[reply]

Banned?[edit]

This was dropped on the article:

“

PPARs drugs are banned as a doping substance under the World Anti-Doping Agency Code since 2009. WADA issued a warning in Mar 2013 although details prompting the sudden announcement is unknown: https://theconversation.edu.au/anti-doping-agency-warns-cheats-on-the-health-risks-of-endurobol-12997

”

This sounds almost like rumour, and a bit more logical explanation would be useful. What might the beneficial effects be of PPAR ligand use? JFW | T@lk 22:35, 24 March 2013 (UTC)[reply]

The effect is mediated specifically by PPARδ and activation of PPARδ increases running endurance (see for example PMID 15328533). Boghog (talk) 22:49, 24 March 2013 (UTC)[reply]

Assessment comment[edit]

The comment(s) below were originally left at Talk:Peroxisome proliferator-activated receptor/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

It does not appear that this article reads like an encyclopedia article. It is typical of wikipedia articles in the field of biology and chemistry as it is only understandable by someone with the equivalent of a degree in biology or biochem. It is full of jargon and does not discuss the system level impact or effects of the material in the article in a way that a layman can understand. Rather, it reads more like an excerpt from an advanced text or paper from the field.

Last edited at 15:48, 5 September 2007 (UTC). Substituted at 02:39, 30 April 2016 (UTC)