Talk:Peter K. Gregersen

Key Publications

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Extended content

Key publications Gregersen PK, Gallerstein P, Jaffe W, and Enlow RW. Valvular heart disease associated with juvenile onset ankylosing spondylitis: A case report and review of the literature. Bulletin, Hospital for Joint Diseases, 42:103114, 1982. Toguchi T, Burmester GR, Nunez-Roldan A, Gregersen PK, Seremetis S, Lee S, Szer IS, Hurley CK, and Winchester RJ. Evidence for the separate molecular expression of four distinct polymorphic Ia epitopes on cells of DR4 homozygous individuals. Human Immunol.10:69-81, 1984. Lee SH, Gregersen PK, Shen HH, Nunez-Roldan A, Silver J, and Winchester RJ. Strong association of rheumatoid arthritis with the presence of a polymorphic Ia epitope defined by a monoclonal antibody: comparison with the allodeterminant DR4. Rheum Int. 4: (Suppl):17-23, 1984. Gregersen PK, Shen M, Song QK, Merryman P, Degar S, Seki T, Maccari J, Goldberg D, Murphy H, Schwenzer J, Wang CY, Winchester RJ, Nepom GT, and Silver J. Molecular diversity of HLA-DR4 haplotypes. Proc. Nat. Acad. Sci. 83:2642-2646,1986. Karr R, Gregersen PK, Obata F, Goldberg D, Maccari J, Alber C, and Silver J. Analysis of DR and DQ chain cDNA clones from DR7 haplotype. J. Immunol. 137:2886-2890, 1986. Gregersen PK, Moriuchi T, Karr RW, Obata F, Maccari J, Goldberg D, Winchester RJ, and Silver J. Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: Implications for the mechanisms of variation.Proc. Nat. Acad .Sci. 83:9149-9153, 1986. Gregersen PK, Goyert S, Song QL, and Silver J. Microheterogeneity of HLA-DR4 haplotypes: DNA sequence analysis of LD "KT2" and LD "TAS" haplotypes. Human Immunol.19:287-292, 1987. Gregersen PK, Silver J, and Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of rheumatoid arthritis susceptibility. Arthritis Rheum, 30:1205-1213, 1987. Seyfried C, Gregersen PK, Nepom B, and Nepom G. Functional polymorphisms among HLA-DR4+ DR chains associated with limited peptide diversity. Molecular Immunol. 24:471-477, 1987. Song Q, Gregersen PK, Karr R, and Silver J. Recombination between DQ and DQ generates HLA class II haplotype diversity. J Immunol. 139:2993, 1987. Hurley C, Gregersen PK, Steiner N, Silver J, Bell J, Hartzman R, Radka S, Nepom G, and Johnson A. Polymorphism of the HLA-D region in American Blacks: a DR3 haplotype generated by recombination. J Immunol. 140:885-892, 1988. Merryman P, Gregersen PK, Lee S, Silver J, Nunez-Roldan A, Crapper R, and Winchester R. Nucleotide sequence of a DRw10 beta chain cDNA clone; identity of the third D region with that of the DRw53 allele of the β2 locus and as the probable site encoding a polymorphic MHC class II epitope. J. Immunol.140:2447-2452, 1988. Hurley CK, Ziff BL, Steiner N, Gregersen PK, and Silver J. DR and DQ beta cDNA sequences associated with a DR2 haplotype. Human Immunol. 22:179-184, 1988. Hurley CK, Ziff BL, Silver J, Gregersen PK, Hartman R, and Johnson AH. Identification of a DRl β-chain determinant in American blacks recognized in the mixed lymphocyte reaction. J. Immunol.140:4019-4023, 1988. Gregersen PK, Kao H-T, Nunez-Roldan A, Hurley CK, Karr R, and Silver J. Recombination sites in the HLA class II region are haplotype dependent. J Immunol. 141:1365-1368, 1988. Klohe EP, Watts R, Bahl M, Alber C, Yu W, Anderson R, Silver J, Gregersen PK, and Karr RW. Analysis of the molecular specificities of anti class II monoclonal antibodies by using L cell transfectants express in HLA class II molecules J. Immunol. 141:2158, 1988. Hurley CK, Gregersen PK, Gorski J, Steiner N, Robbins F, Hartman R, Johnson AH, and Silver J. DR3(w18) DQw4 haplotype differs from DR3(w17) DQw2 haplotypes at multiple class II loci. Human Immunol. 25:37-50, 1989. Merryman, P, Crapper, RM, Lee, S, Gregersen PK, and Winchester RJ. Class II major histocompatibility complex gene sequences in rheumatoid arthritis: the third diversity regions of both DR beta genes in two DRl, DRw10-positive individuals specify the same inferred amino acid sequence as the DRβl and DRβ2 genes of a DR4 (Dw14) haplotype. Arthritis Rheum. 32 (3):251-258, 1989. Navarrete C, Seki T, Miranda A, Winchester R, and Gregersen PK. DNA sequence analysis of the HLA-DR12 allele, Human Immunol, 25:51-58,1989. Kao H-T, Gregersen PK, Tang JC, Takahashi T, Wang CY, and Silver J. Molecular analysis of the HLA class II genes in two DRw6 related haplotypes, DRw13 DQwl and DRw14 DQw3 J. Immunol. 142:1743-1747, 1989. Merryman P, Silver J, Gregersen PK, Solomon G, and Winchester R. A novel association of DQ and DQβ genes in the DRwIO haplotype: determination of a DQwl specificity by the DQβ chain. J. Immunol., 143:2068-2073, 1989. Lang B, Navarrete C, LoGalbo PR, Nepom GT, Silver J, Winchester RJ, and Gregersen PK. Further DNA sequence microheterogeneity of the HLA-DR4/Dw13 haplotype group: Importance of amino acid position 86 of the DRβl chain for T cell recognition.Human Immunology. 27:378-389, 1990. Itescu S, Brancato L, Solomon G, Gregersen PK, Buxbaum J, and Winchester RJ. Diffuse infiltrative lymphocytosis syndrome (DILS) in HIV infection: a host immune response associated with HLA-DR5. Annals of Int. Medicine 112:3, 1990. Celis E, Karr RW, Gregersen PK, and Reinsmoen NL. Functional analysis of MHC class II restricted T cells derived from a caucasian with a DR4 Dw15 DQw8 haplotype. Human Immunology. 29:31-41, 1990. Kaufman LD, Gruber BL, and Gregersen PK. The eosinophilia-myalgia syndrome: clinical follow-up and immunogenetic studies of 32 patients. Lancet, 337:1071-1074, 1991. Gulwani-Akolkar B, Posnett DN, Janson CH, Grunewald J, Wigzell H, Akolkar P, Gregersen PK, and Silver J. T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type. J. Exp. Med. 174:1139-1146, 1991. Hashimoto S, Gregersen PK, and Chiorazzi N. The human Ig-β cDNA sequence,a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig Isotopes. J.Immunol.150:491-498, 1993. Molkentin J, Gregersen PK, Lin X, Zhu N, Wang Y, Wang Y, Chen S, Chen S, Baxter-Lowe L, and Silver J. Molecular analysis of HLA-DRβ and DQβ polymorphism in Chinese with rheumatoid arthritis. Annals of the Rheumatic Diseases, 52:610-612, 1993. Gregersen P.K. Discordance for autoimmunity in monozygotic twins - are "identical" twins really identical? Arthritis and Rheumatism, 36:1185-1192, 1993. Hingorani R, Choi I-H, Akolkar P, Gulwani-Akolkar B, Pergolizzi R, Silver J, and Gregersen PK. Clonal Dominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects J. Immunol. 151:5762-5769, 1993. Hashimoto S, Chiorazzi N, and Gregersen PK. The complete sequence of the human CD79 (Igβ/B29) gene: identification of conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. Immunogenetics 40:145-149, 1994. Hashimoto S, Mohrenweiser H W, Gregersen PK, and Chiorazzi N. Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79a (Ig-a/mb1) gene. Immunogenetics 40:287-295, 1994. Trejo V, Derom C, Vlietinck R, Ollier WER, Silman A, Ebers G,Derom R, and Gregersen PK. X chromosome inactivation patterns correlate with fetal-placental anatomy in monozygotic twin pairs: implications for immune relatedness and concordance for autoimmunity. Molecular Medicine, 1:62-70, 1994. Morley JK, Batliwalla F, Hingorani R, and Gregersen PK. Oligoclonal CD8+ T cells are preferentially expanded in the CD57+ subset. J. Immunol. 154:6182-6190, 1994. Monteiro J, Hingorani R, Choi I-H, Silver J, Pergolizzi R, and Gregersen PK. Oligoclonality in the human CD8+ T-cell repertoire in normal subjects and monozygotic twin pairs: implications for studies of infectious and autoimmune diseases. Molecular Medicine 1:614, 1995. Dono M, Hashimoto S, Fais F, Trejo V, Allen S, Lichtman SM, Schulman P, Vinciguerra VP, Sellars B, Gregersen PK, Ferrarini M, and Chiorazzi N. Evidence for IgM+ progenitors of IgG+ CLL B cells that undergo intraclonal differentiation and diversification. Blood 87:1586, 1996. Hingorani R, Monteiro J, Furie R, Chartash E, Navarrete C, Pergolizzi R, and Gregersen PK. Oligoclonality of TCRBV3 chains in the CD8+ T cell population of rheumatoid arthritis patients. J. Immunol. 156:852, 1996. Monteiro J, Batliwalla F, Ostrer H, and Gregersen, PK. Shortened telomeres on clonality expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J.Immunol. 156:3587-3590, 1996. Monteiro J, Hingorani R, Pergolizzi R, Apatoff B, and Gregersen, PK. Oligoclonality of CD8+ T cells in multiple sclerosis. Autoimmunity 23:127-138, 1996. Fais F, Sellars B, Ghiotto F, Yan X, Dono M, Allen SL, Budman K, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Schuster M, Vinciguerra V, Rai K, Stevenson FK, Gregersen PK, Ferrarini M, and Chiorazzi N. J. Clin Invest. 98:1659-1666, 1996. Batliwalla F, Monteiro J, Serrano D, and Gregersen, PK. Oligoclonality of CD8+ T cells in health and disease: aging, infection, or immune regulation? Human Immunology 48, 68-76, 1996. Jawaheer D, MacGregor AJ, Gregersen, PK, Silman AJ, and Ollier WER. Unexpected HLA haplotype sharing in dizygotic twin pairs discordant for rheumatoid arthritis. J. Med Genetics, 33:1015-1018, 1996. Serrano D, Monteiro J, Allen SL, Kolitz J, Schulman P, Lichtman SM, Buchbinder A, Vinciguerra VP, Chiorazzi N, and Gregersen PK. Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia. J.Immunol., 158: 1482-1489, 1997. Mobini N, Yunis EJ, Alper CA, Yunis JJ, Delgado JC, Yunis DE, Firooz A, Dowlati Y, Bahar K, Gregersen PK, Ahmed AR Identical MHC markers in non-Jewish Iranian and Ashkenazi Jewish patients with pemphigus vulgaris: possible common central Asian ancestral origin. Hum Immunol 1997 Sep 15;57(1):62-7 Monteiro J. Derom C, Vlietinck R, Kohn N, Lesser M and Gregersen PK. Commitment to X inactivation precedes the twinning event in monochorionic MZ twins. Am. J. of Human Genetics 63:339-346, 1998 Ivanova S, Botchkina G, Al-Abed Y, Miestrell M, Batliwalla F, Dubinsky JM, Iadecola C, Wang H, Gregersen PK, Eaton JW and Tracy KJ. Cerebral Ischemia enhances polyamine oxidation: identification of enzymaytically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death. J. Exp. Med. 188:327-340, 1998. Herbein G, Mahlknecht U, Batliwalla F, Gregersen PK, Pappas T, Butler J, O’Brien WA and Verdin E. Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chomokine receptor CXCR4. Nature 395:189-194, 1998. Eiraku N, Hingorani R, Shinji I, Machigashira K, Gregersen PK, Monteiro J, Usuku K, Yashiki S, Sonoda S, Osame M and Hall WW. Clonal expansion within CD4+ and CD8+ T cell subsets in huyman T lymphotropic virus type 1 infected individuals. J. Immunol. 161:6674-6680, 1998 Batliwalla F, Bateman B, Serrano D, Murray D, Macphail S, Maino V, Ansel JC, Gregersen PK and Armstrong CA. A fifteen year follow up of AJCC stage II malignant melanoma patients treated postsurgically with Newcastle disease virus: correlation with alterations in the CD8+ T cell repertoire. Molecular Medicine 4:783-794, 1998 Gregersen PK, Chitnis S, and Monteiro J. Increased X-inactivation skewing in SLE?. Immunology Today 20:156, 1999 Seldin M, Amos C, Ward R and Gregersen PK. The genetics revolution and the assault on rheumatoid arthritis. Arthritis and Rheumatism, 42(6):1071-9.1999. 51. Chitnis S, Derom C, Vlietinck R, Monteiro J and Gregersen PK. X chromosome inactivation patterns confirm the late timing of monoamnionic monozygotic (MA-MZ) twinning. Am J Hum Genetics 65(2):570-1, 1999. Gregersen PK, Kowalsky E, Kohn N and Marvin EW. Absolute pitch: prevalence, ethnic variation, and estimation of the genetic component. Am J Hum Genet 65(3):911-3, 1999 Monteiro J, Derom C, Vlietinck R, Kohn N, Lesser M, and Gregersen PK. Commitment to X inactivation precedes the twinning event in monochorionic MZ twins. Am J Human Genetics 63:339-346, 1998. Gregersen PK, Chitnis S, and Monteiro J. Increased X-inactivation skewing in SLE? Immunology Today 20:156, 1999. \ Than S, Kharbanda M, Chitnis V, Bakshi S, Gregersen PK, Pahwa S. Clonal dominance patterns of CD8 T cells in relation to disease progression in HIV-infected children. J Immunol. 1999 Mar 15;162(6):3680-6. Seldin M, Amos C, Ward R, and Gregersen PK. The genetics revolution and the assault on rheumatoid arthritis. Arthritis Rheum 42(6):1071-1079, 1999. Chitnis S, Derom C, Vlietinck R, Monteiro J, and Gregersen PK. X chromosome inactivation patterns confirm the late timing of monoamnionic monozygotic (MA-MZ) twinning. Am J Human Genetics 65(2):570-571, 1999. Gregersen PK, Kowalsky E, Kohn N, and Marvin EW. Absolute pitch: Prevalence, ethnic variation, and estimation of the genetic component. Am J Human Genetics 65(3):911-913, 1999. Hirose N, Williams R, Alberts AR, Furie RA, Chartash EK, Jain RI, Sison C, Lahita RG, Merrill JT, Cucurull E, Gharavi AE, Sammaritano LR, Salmon JE, Hashimoto S, Sawada T, Chu CC, Gregersen PK, Chiorazzi N.A role for the polymorphism at position 247 of the beta2-glycoprotein I gene in the generation of anti-beta2-glycoprotein I antibodies in the antiphospholipid syndrome. Arthritis Rheum. 1999 Aug;42(8):1655-61 Chitnis S, Monteiro J, Glass D, Apatoff B, Salmon J, Concannon P and Gregersen PK The role of X chromosome inactivation in female predisposition to autoimmunity. Arthritis Research 2000, "http://arthritis-research.com/content/2/5/399" Batliwalla F, Rufer N, Lansdorp P and Gregersen PK. Oligoclonal expansions in the CD8 - CD28- T cells largely explain the shorter telomeres detected in this subset: analysis by flow FISH. Human Immun, 61:951-58,2000. Gregersen PK, Kowalsky E, Kohn N and Marvin EW. Early childhood music education and predisposition to absolute pitch: teasing apart genes and environment. Am. J. Med. Genetics, 98:280-282, 2000. Batliwalla F, Damle RN, Chiorazzi N and Gregersen PK. Simultaneous flow cytometric analysis of cell surface markers and telomere length: analysis of human tonsillar B cells. J. Immunol. Methods, 247:103-9,2001. Chitnis S, Monteiro J, Glass D, Apatoff B, Salmon J, Concannon P, and Gregersen PK. The role of X chromosome inactivation in female predisposition to autoimmunity. Arthritis Res 2:399-406, 2000. (http://arthritis-research.com/content/2/5/399). Batliwalla F, Rufer N, Lansdorp P, and Gregersen PK. Oligoclonal expansions in the CD8 CD28- T cells largely explain the shorter telomeres detected in this subset: Analysis by flow fish. Human Immunol 61:951-958, 2000. Damle RN, Fais F, Ghiotto F, Valetto A, Albesiano E, Wasil T, Batliwalla FM, Allen SL, Schulman P, Vinciguerra VP, Rai KR, Gregersen PK, Ferrarini M, Chiorazzi N.Chronic lymphocytic leukemia: a proliferation of B cells at two distinct stages of differentiation. Curr Top Microbiol Immunol. 2000;252:285-92 Gregersen PK, Kowalsky E, Kohn N, and Marvin EW. Early childhood music education and predisposition to absolute pitch: Teasing apart genes and environment. Am J Med Genetics 98:280-282, 2000. Batliwalla F, Damle RN, Chiorazzi N, and Gregersen PK. Simultaneous flow cytometric analysis of cell surface markers and telomere length: Analysis of human tonsillar B cells. J Immunol Methods 247:103-109, 2001. Jawaheer D, Seldin MF, Amos CI, Chen WV, Shigeta R, Monteiro J, Kern M, Criswell LA, Albani S, Nelson JL, Clegg DO, Pope R, Schoeder HW, Bridges SL Jr, Pisetsky DS, Ward R, Kastner DL, Wilder RL, Pincus T, Callahan LF, Flemming D, Wener MH, and Gregersen PK. A genome-wide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am J Human Genetics 68(4): 927-936, 2001. Baugh JA, Chitnis S, Donnelly SC, Monteiro J, Lin X, Plant BJ, Wolfe F, Gregersen PK, and Bucala R. A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis. Genes Immunity 3:170-176, 2002 Hofmann MA, Drury S, Hudson BJ, Gleason MR, Qu W, Lu Y, Lalla E, Chitnis S, Monteiro J, Stickland MH, Bucciarelli LG, Moser B, Moxley G, Itescu S, Grant PJ, Gregersen PK, Stern DM, and Schmidt AM. Rage and arthritis: The G82S polymorphism amplifies the inflammatory response. Genes Immunity 3:123-135 2002 Chavan SS, Tian W, Hsueh K, Jawaheer D, Gregersen PK, Chu CC. Characterization of the human homolog of the IL-4 induced gene-1 (Fig1). Biochim Biophys Acta. 2002 Jun 7;1576(1-2):70-80. Ivanova, S., F. Batliwalla, J. Mocco, S. Kiss, J. Huang, W. Mack, A. Coon, J. W. Eaton, Y. Al-Abed, P. K. Gregersen, E. Shohami, E. S. Connolly, Jr., and K. J. Tracey., Neuroprotection in cerebral ischemia by neutralization of 3- aminopropanal. Proc Natl Acad. Sci U S A 99: 5579-84, 2002 Jawaheer, D., W. Li, R. R. Graham, W. Chen, A. Damle, X. Xiao, J. Monteiro, H. Khalili, A. Lee, R. Lundsten, A. Begovich, T. Bugawan, H. Erlich, J. T. Elder, L. A. Criswell, M. F. Seldin, C. I. Amos, T. W. Behrens, and P. K. Gregersen Dissecting the Genetic Complexity of the Association between Human Leukocyte Antigens and Rheumatoid Arthritis. Am J Hum Genet 71:585-94, 2002 Graham, R. R., W. A. Ortmann, C. D. Langefeld, D. Jawaheer, S. A. Selby, P. R. Rodine, E. C. Baechler, K. E. Rohlf, K. B. Shark, K. J. Espe, L. E. Green, R. P. Nair, P. E. Stuart, J. T. Elder, R. A. King, K. L. Moser, P. M. Gaffney, T. L. Bugawan, H. A. Erlich, S. S. Rich, P. K. Gregersen, and T. W. Behrens. Visualizing Human Leukocyte Antigen Class II Risk Haplotypes in Human Systemic Lupus Erythematosus. Am J Hum Genet 71:543-553, 2002 Gruber SB, Ellis NA, Scott KK, Almog R, Kolachana P, Bonner JD, Kirchhoff T, Tomsho LP, Nafa K, Pierce H, Low M, Satagopan J, Rennert H, Huang H, Greenson JK, Groden J, Rapaport B, Shia J, Johnson S, Gregersen PK, Harris CC, Boyd J, Offit K. BLM heterozygosity and the risk of colorectal cancer. Science. 2002 Sep 20;297(5589):2013 Foulkes WD, Thiffault I, Gruber SB, Horwitz M, Hamel N, Lee C, Shia J, Markowitz A, Figer A, Friedman E, Farber D, Greenwood CM, Bonner JD, Nafa K, Walsh T, Marcus V, Tomsho L, Gebert J, Macrae FA, Gaff CL, Paillerets BB, Gregersen PK, Weitzel JN, Gordon PH, MacNamara E, King MC, Hampel H, De La Chapelle A, Boyd J, Offit K, Rennert G, Chong G, Ellis NA. The founder mutation MSH2*1906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population. Am J Hum Genet. 2002 Dec;71(6):1395-412 Jawaheer D, Seldin MF, Amos CI, Chen WV, Shigeta R, Etzel C, Damle A, Xiao X, Chen D, Lum RF, Monteiro J, Kern M, Criswell LA, Albani S, Nelson JL, Clegg DO, Pope R, Schroeder HW, Jr., Bridges SL, Jr., Pisetsky DS, Ward R, Kastner DL, Wilder RL, Pincus T, Callahan LF, Flemming D, Wener MH, Gregersen PK: Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families. Arthritis Rheum 48:906-16., 2003 Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW: Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A 25:25, 2003 Ulloa L, Batliwalla FM, Andersson U, Gregersen PK, Tracey KJ: High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis. Arthritis Rheum 48:876-81,2003 Gregersen, P. K. and R. Bucala, MIF, Mif alleles, and the Genetics of Inflammatory Disorders: Incorporating Disease Outcome into the Definition of Phenotype. Arthritis and Rheum. 48:1171-1176, 2003. Offit K, Pierce H, Kirchhoff T, Kolachana P, Rapaport B, Gregersen P, Johnson S, Yossepowitch O, Huang H, Satagopan J, Robson M, Scheuer L, Nafa K, Ellis N. Frequency of CHEK2*1100delC in New York breast cancer cases and controls.BMC Med Genet. 2003 Jan 15;4(1):1 Jawaheer D, Juo SH, Le Caignec C, David A, Petit C, Gregersen P, Dowbak S, Damle A, McElreavey K, Ostrer H. Mapping a gene for 46,XY gonadal dysgenesis by linkage analysis. Clin Genet. 2003 Jun;63(6):530-5. Jawaheeer D, Lum R, Gregersen PK, Amos C, and Criswell L. Familial aggregation of rheumatoid arthritis: demographic and clinical characteristics of 512 multicase families. Arthritis and Rheumatism, 50:736-41, 2004. Li W, Gregersen PK. Reconstructing haplotypes in pedigrees: importance of parental information.Am J Med Genet. 2004 Jan 1; 124A(1): 107-9. Damle RN, Batliwalla FM, Ghiotto F, Valetto A, Albesiano E, Sison C, Allen SL, Kolitz J, Vinciguerra VP, Kudalkar P, Wasil T, Rai KR, Ferrarini M, Gregersen PK, Chiorazzi N. Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by Ig V gene mutations. Blood. 2004 Jan 15; 103(2): 375-82.. Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH, Gregersen PK, Wu Y, Achkar JP, Dassopoulos T, Mezey E, Bayless TM, Nouvet FJ, Brant SR. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet. 2004 Jan 1; 13(1): 35-45 Killian MS, Monteiro J, Matud J, Hultin LE, Hausner MA, Yang OO, Gregersen PK, Detels R, Giorgi JV, Jamieson BD.Persistent alterations in the T-cell repertoires of HIV-1-infected and at-risk uninfected men. AIDS. 2004 Jan 23;18(2):161-70. Mitchell MK, Gregersen PK, Johnson S, Parsons R, Vlahov D.The New York Cancer project: rationale, organization, design, and baseline characteristics. J Urban Health. 2004 Jun;81(2):301-10. Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Moser K, Ortmann WA, Espe KJ, Balasubramanian S, Hughes KM, Chan JP, Begovich A, Chang SY, Gregersen PK, Behrens TW.Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation. Genes and Immunity (2004) 5, 347–353 Begovich A, Carlton VE, Honigberg L, Schrodi SJ. Chokkalingam A. Alexander H, Ardlie K, Huang Q, Smith AM, Spoerke J, Conn MP, Chang M, Chang SY, Saiki R, Catanese JJ, Leong D, Garcia V, Jeffery D, Lee A, Batliwalla F, Remmers EF, Criswell LA, Seldin MF, Kastner DL, Amos CI, Sninsky JJ, &. Gregersen PK. A missense SNP in the protein tyrosine phosphastase PTPN22 is associated with rheumatoid arthritis. Am J. Hum Genet 75:330-337, 2004 Kyogoku C, Langfeld CD, Ortmann WA, Lee A, Selby S, Carlton V, Chang M, Ramos P, Baechler EC, Batliwalla F, Novitzke J, Williams AH, Gillett C, Rodine P, Graham R, Gaffney P, Moser K, Petri M, Begovich AB, Gregersen PK and Behrens TW. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am. J. Human Genet 75:504-507, 2004 Smith GS, Lotrich FE, Malhotra AK, Lee AT, Ma Y, Kramer E, Gregersen PK, Eidelberg D, Pollock BG. Effects of serotonin transporter promoter polymorphisms on serotonin function. Neuropsychopharmacology. 29:2226-34, 2004 Lee AT, Li W, Liew A, Bombardier C, Weisman M, Massarotti EM, Kent J,Wolfe F, Begovich A and Gregersen PK (2004). The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose dependent manner but not with HLA shared epitope status. Genes and Immunity 6:129-133, 2005 Criswell LA, Pfeiffer KA, Lum RF, Gonzales B, Novitzke J, Kern M, Moser KL, Begovich AB, Carlton VE, Li W, Lee AT, Ortmann W, Behrens TW, Gregersen PK.Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes. Am J Hum Genet. 76:561-71, 2005 Batliwalla FM, Baechler EC, Xiao X, Balasubramanian S, Li W, Kern M, Gulko PS, Ortmann W, Perrone A, Kantor AB, Furie R, Behrens TW, Gregersen PK. Peripheral blood gene expression profiling in rheumatoid arthritis. Genes Immun. 2005 Aug;6(5):388-97. Addo A, Le J, Li W, Aksentijevich I, Balow J Jr, Lee A, Gregersen PK, Kastner DL, Remmers EF. Analysis of CARD15/NOD2 haplotypes fails to identify common variants associated with rheumatoid arthritis susceptibility. Scand J Rheumatol. 2005 May-Jun;34(3):198-203. Behrens TW, Graham RR, Kyogoku C, Baechler EC, Ramos PS, Gillett C, Baue J, Ortmann WA, Hippen KL, Peterson E, Langefeld CD, Moser KL, Gaffney PM, Gregersen PK. Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus. Novartis Found Symp. 2005;267:145-60; discussion 160-4. Carlton VE, Hu X, Chokkalingam AP, Schrodi SJ, Brandon R, Alexander HC, Chang M, Catanese JJ, Leong DU, Ardlie KG, Kastner DL, Seldin MF, Criswell LA, Gregersen PK, Beasley E, Thomson G, Amos CI, Begovich AB. PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet. 2005 Oct;77(4):567-81. Yang N, Li H, Criswell LA, Gregersen PK, Alarcon-Riquelme ME, Kittles R,Shigeta R, Silva G, Patel PI, Belmont JW, Seldin MF. Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine. Hum Genet. 2005 Sep 29;:1-11 Hofmann MA, Yang Q, Harja E, Kedia P, Gregersen PK, Cupples LA, Schmidt AM, Hudson BI. The RAGE Gly82Ser polymorphism is not associated with cardiovascular disease in the Framingham offspring study. Atherosclerosis. 2005 Oct;182(2):301-5. Derom C, Jawaheer D, Chen WV, McBride KL, Xiao X, Amos C, Gregersen PK, Vlietinck R. Genome-wide linkage scan for spontaneous DZ twinning. Eur J Hum Genet. 2005 Nov 16; Huizinga TW, Amos CI, van der Helm-van Mil AH, Chen W, van Gaalen FA, Jawaheer D, Schreuder GM, Wener M, Breedveld FC, Ahmad N, Lum RF, de Vries RR, Gregersen PK, Toes RE, Criswell LA. 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Nassir R, Kosoy R, Tian C, White PA, Butler LM, Silva G, Kittles R, Alarcon-Riquelme ME, Gregersen PK, Belmont JW, De La Vega FM, Seldin MF.An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels.BMC Genet. 2009 Jul 24;10:39. Santiago JL, Li W, Lee A, Martinez A, Chandrasekaran A, Fernandez-Arquero M, Khalili H, de la Concha EG, Urcelay E, Gregersen PK.Localization of Type 1 Diabetes susceptibility in the ancestral haplotype 18.2 by high density SNP mapping.Genomics. 2009 Oct;94(4):228-32. Epub 2009 Jul 8. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH, Booty M, Estes JD, Sandler NG, Plass N, Stone DL, Turner ML, Hill S, Butman JA, Schneider R, Babyn P, El-Shanti HI, Pope E, Barron K, Bing X, Laurence A, Lee CC, Chapelle D, Clarke GI, Ohson K, Nicholson M, Gadina M, Yang B, Korman BD, Gregersen PK, van Hagen PM, Hak AE, Huizing M, Rahman P, Douek DC, Remmers EF, Kastner DL, Goldbach-Mansky R.An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med. 2009 Jun 4;360(23):2426-37. Gregersen PK, Silver J, and Winchester RJ. Genetic susceptibility to rheumatoid arthritis: the role of shared conformational determinants. Am J Med. 85 (suppl.6A): 17,1988. Winchester R and Gregersen PK: The molecular basis of susceptibility to rheumatoid arthritis: the conformational equivalence hypothesis. Springer Semin. Immunopathol. 10:119-139,1988. Winchester RJ and Gregersen PK. Hypotheses on the molecular basis of susceptibility to rheumatoid arthritis. Rheumatologie, 40:9:329-333, 1988. Ziff BL, Hurley CK, Rosen-Bronson S, Tang T, Hartzman R, Silver J, Gregersen PK, Eckels D, and Johnson AH. Polymorphism of the DR1 Haplotype: Structural and Functional Analysis. Immunobiology of HLA, Immunogenetics and Histocompatibility, 2:187-89, 1989. Johnson AH, Fang-Tang T, Rosen-Bronson S, Robbins FM, Steiner N, Hartzman RJ, and Gregersen PK, Silver J, Ziff B, Hurley CK. DR3 Heterogeneity in American Blacks. Immunobiology of HLA, Immunogenetics and Histocompatibility, 2:202-03,1989. Crapper RM, Gregersen PK, Lee SH, Nunez-Roldan A, Merryman P, and Winchester RJ. A Novel DR51 (DRw11) Chain with a Distinctive Third Diversity Region. Immunobiology of HLA, Immunogenetics and Histocompatibility, 2:212-13,1989. Takahashi TC, Kao HT, Tang TP, Gregersen PK, Silver J, and Wang CY. Molecular Diversity of HLA-DRw6 haplotypes. Immunobiology of HLA, Immunogenetics and Histocompatibility, 2:218-19,1989. Lee SH, Nunez-Roldan A, Merryman P, Gregersen PK, Crapper RM, and Winchester RJ. Molecular Definition of the DRw10 Haplotype. Immunobiology of HLA, Immunogenetics and Histocompatibility, 2:232-34,1989. Hurley CK, Steiner N, Gregersen PK, Silver J, Hartzman R, Nepom G, and Johnson AH. Evolution of DQw2-related Haplotypes. Immunobiology of HLA, Immunogenetics and Histocompatibility, 2:283-285,1989. Gregersen PK, Barr KM, DeFeo C, Bystryn C, Franks A, Sanchez B, Silver J, Winchester RJ, and Nunez-Roldan A. DRB1 Chain Polymorphism in Pemphigus Vulgaris. Immunobiology of HLA, Immunogenetics and Histocompatibility, 2:432-33,1989. Gregersen PK, Todd JA, Erlich HA, Long E, Servenius B Choi E, Kao HT, and Lee JS. First Domain Sequence Diversity of DR and DQ subregion alleles. Immunobiology of HLA, Immunogenetics and Histocompatibility,1:1027-31,1989. Gregersen PK. HLA class II polymorphism: implications for genetic susceptibility to autoimmune disease. Laboratory Investigation, 61:5-19, 1989. Reprinted in Pathology Reviews, 81-95,1990. Gregersen PK. HLA association with rheumatoid arthritis: a piece of the puzzle. Proceedings of the Dunlop Symposium, Montreal, 1991. J Rheumatology, 19/S32:7-11,1992. Gregersen PK. T cell receptor-major histocompatibility complex in genetic interactions in rheumatoid arthritis. Rheum. Disease Clinics of North America, 18:793-805,1992. Gregersen PK, Hingorani R, and Monteiro J. Oligoclonality in the CD8+ T cell population: analysis using a multiplex PCR assay for CDR3 length. Ann NY Academy of Sciences, 756:19-27,1995. Monteiro J, Hingorani R, Pergolizzi R, Apatoff B, and Gregersen PK. Clonal dominance in CD8+ T cells in multiple sclerosis. Ann NY Academy of Sciences, 756:310-312, 1995. Monteiro J, Hingorani R, Choi I, Pergolizzi R, Silver J, and Gregersen PK. Variability in CD8+ T cell oglioclonality in monozygotic twins. Ann NY Academy of Sciences, 756:19-27, 1995. Patki V, Monteiro J, Gregersen PK, and Chiorazzi N. Evidence for B cell Oligoclonality in the blood and joints of patients with rheumatoid arthritis. Ann NY Academy of Sciences, 815:472-474,1997. Gregersen PK. The North American Rheumatoid Arthritis Consortium-bringing genetic analysis to bear on disease susceptibility, severity, and outcome. Arthritis Care and Research, 11:1,1998. Gregersen PK. Invited Editorial. Instant Recognition: The Genetics of Pitch Perception. The American Journal of Human Genetics, 62:221-223,1998. Gregersen PK. Genetics of rheumatoid arthritis: confronting complexity. Arthritis Res 1:37-44, 1999. (http://arthritis-research.com/content/1/1/37). Gregersen PK. Genetics and rheumatic diseases: rheumatoid arthritis and ankylosing spondylitis. The genetics of rheumatoid arthritis. Bull Rheum Dis. 2001;50(2):1-2. Gregersen PK. Pregnant with controversy. J Rheumatol. 2000 Dec;27(12):2738-9. Jawaheer, D. and P.K. Gregersen, The search for rheumatoid arthritis susceptibility genes: a call for global collaboration. Arthritis Rheum 46: 582-4, 2002 Jawaheer D, and Gregersen PK. Rheumatoid arthritis: The genetic components. Rheum Dis Clin N America 28:1-15, 2002. Gregersen PK. Teasing apart the complex genetics of human autoimmunity: lessons from rheumatoid arthritis. Clin Immunol. 2003 Apr;107(1):1-9. Gregersen PK, Brehrens TW: Fine mapping the phenotype in autoimmune disease: the promise and pitfalls of DNA microarray technologies. Genes Immun 4:175-6, 2003 Baechler EC, Gregersen PK, Behrens TW. The emerging role of interferon in human systemic lupus erythematosus. Curr Opin Immunol. 2004 Dec;16(6):801-7. Metz CN, Gregersen PK, Malhotra AK. Metabolism and biochemical effects of nicotine for primary care providers. Med Clin North Am. 2004 Nov;88(6):1399-413 Gregersen P.K. Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond Immunological Reviews 2005, 204:74-86 Gregersen PK and Batliwalla F. 2005. PTPN22 and rheumatoid arthritis: gratifying replication. Arthritis and Rhematism, 52:1952-5 Gregersen PK. Gaining insight into PTPN22 and autoimmunity. Nat. Genetics 2005 Dec;37(12):1300-2 Baechler EC, Batliwalla FM, Reed AM, Peterson EJ, Gaffney PM, Moser KL, Gregersen PK, Behrens TW. Gene expression profiling in human autoimmunity. 1: Immunol Rev. 2006 Apr;210:120-37. Gregersen PK and Behrens TW.Genetics of autoimmune diseases—disorders of immune homeostasis. Nat Rev Genet. 2006 Dec;7(12):917-28. Review. Gregersen PK. Modern genetics, ancient defenses, and potential therapies. N Engl J Med. 2007 ;356(12):1263-6. Roubenoff R, Beckman E, Weinblatt M, Shadick N, Gregersen PK. Comment on: Ann Intern Med. 2007 Jun 5;146(11):797-808. Biological significance of anti-cyclic citrullinated peptide antibody in rheumatoid arthritis. Ann Intern Med. 2008 Mar 4;148(5):403 PMID 18316760 Korman BD, Kastner DL, Gregersen PK, Remmers EF.STAT4: genetics, mechanisms, and implications for autoimmunity. Curr Allergy Asthma Rep. 2008 Sep;8(5):398-403.PMID 18682104 Coenen MJ, Gregersen PK. Rheumatoid arthritis: a view of the current genetic landscape. Genes Immun. 2008 Nov 6. [Epub ahead of print] Tian C, Gregersen PK, Seldin MF Accounting for ancestry: population substructure and genome-wide association studies. Hum Mol Genet. 2008 Oct 15;17(R2):R143-50 Gregersen PK, Olsson LM. Recent advances in the genetics of autoimmune disease. Annu Rev Immunol. 2009;27:363-91. Gregersen PK. Closing the gap between genotype and phenotype.Nat Genet. 2009 Sep;41(9):958-9

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