Talk:Pore-forming toxin

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Untitled[edit]

Created Bassophile 15:59, 10 January 2007 (UTC)[reply]

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Move of article from "Pore-forming toxin" to "Pore-forming protein"[edit]

I don't agree with the recent move of the article from "Pore-forming toxin" to "pore-forming protein." Gram-negative bacteria make plenty of pore-forming outer membrane proteins that aren't exotoxins, but this article is only about the toxins. The new title is going to generate confusion. CatPath (talk) 03:50, 15 June 2016 (UTC)[reply]

I just reverted the article back to "Pore-forming toxin." The change to the new title should be discussed first. CatPath (talk) 04:33, 15 June 2016 (UTC)[reply]

@CatPath: Good point - I jumped the gun a bit on that one. T.Shafee(Evo﹠Evo)^talk 04:38, 15 June 2016 (UTC)[reply]

Adding section on acronym origin?[edit]

I always wondered why binary toxin was called CDT. I thought I'd look into it. The first references are in 1987/88 from:

Popoff, M. R., Rubin, E. J., Gill, D. M., & Boquet, P. (1988). Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain. Infection and immunity, 56(9), 2299-2306.
Popoff, M. R., & Boquet, P. (1988). Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin. Biochemical and biophysical research communications, 152(3), 1361-1368.

Oddly, Popoff & Boquet 1988 cites a paper which was unpublished at the time. The authors are French, which makes me wonder if the French equivalent for "ADP-ribosyltransferase" would have a different word order. That's one possibility I've come up with so far. Otherwise, perhaps its an abbreviation for C. difficule transferase?. In the paper it makes no sense as read. It is:

"We have recently isolated an ADP-ribosyl transferase (CDT) from a strain of C. difficile (CD196) which modifies cell actin as C.botulinum C2 component I or iota i_a chain do (II)."

Makes absolutely no sense to me...150.135.214.170 (talk) 21:33, 11 December 2019 (UTC) (JWA posting as anon)[reply]