Talk:Thiomer

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Literature and clinical trials[edit]

Moved here from the article per WP:NOTCATALOG and WP:NOTNEWS. --Zefr (talk) 19:09, 4 January 2018 (UTC)[reply]

Selected review articles

Bernkop-Schnürch A. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems. Int J Pharm 2000;194(1):1-13.
Bernkop-Schnürch A. Thiomers: A new generation of mucoadhesive polymers. Adv Drug Deliv Rev 2004;57(11):1569-82.
Bernkop-Schnürch A., Krauland A.H., Leitner V.M., Palmberger T. Thiomers: potential excipients for non-invasive peptide delivery systems. Eur J Pharm Biopharm. 2004 Sep;58(2):253-63.
Albrecht K. and Bernkop-Schnürch A. Thiomers: forms, functions and applications to nanomedicine. Nanomedicine. 2007 Feb;2(1):41-50.
Jere D., Arote R., Jiang H.L., Kim Y.K., Cho M.H., Cho C.S., Bioreducible polymers for efficient gene and siRNA delivery. Biomed Mater. 2009; 4(2):025020.
Bonengel S, Bernkop-Schnürch A. Thiomers—from bench to market. J Control Release. 2014 Dec 10;195:120-9.
Wirostko B., Mann B.K., Williams D.L., Prestwich G.D., Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel. Adv Wound Care (New Rochelle). 2014, 3(11):708-716.
Islam M.A., Park T.E., Reesor E., Cherukula K., Hasan A., Firdous J., Singh B., Kang S.K., Choi Y.J., Park I.K., Cho C.S. Mucoadhesive chitosan derivatives as novel drug carriers. Curr Pharm Des. 2015; 21(29):4285-309.
Ijaz M, Bernkop-Schnürch A. Preactivated thiomers: their role in drug delivery. Expert Opin Drug Deliv. 2015 Aug;12(8):1269-81.
Shah K.U., Shah S.U., Dilawar N., Khan G.M., Gibaud S., Thiomers and their potential applications in drug delivery. Expert Opin Drug Deliv. 2017; 14(5):601-610.
Duggan S., Cummins W., O' Donovan O., Hughes H., Owens E., Thiolated polymers as mucoadhesive drug delivery systems. Eur J Pharm Sci. 2017; 100:64-78.
Schattling P., Taipaleenmäki E., Zhang Y., Städler B., A polymer chemistry point of view on mucoadhesion and mucopenetration. Macromol Biosci. 2017; 17(9).

Clinical trials

Hornof M., Weyenberg W., Ludwig A. and Bernkop-Schnürch A., Mucoadhesive ocular insert based on thiolated poly(acrylic acid): development and in vivo evaluation in humans. J. Control. Release 2003, 89(3):419-28.
Local Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers
Assessment of Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Subjects While Wearing Contact Lenses and Before Insertion of Contact Lenses
Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation
Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers
Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy
Schmidl D, Werkmeister R, Kaya S, Unterhuber A, Witkowska KJ, Baumgartner R, Höller S, O'Rourke M, Peterson W, Wolter A, Prinz M, Schmetterer L, Garhöfer G., A Controlled, Randomized Double-Blind Study to Evaluate the Safety and Efficacy of Chitosan-N-Acetylcysteine for the Treatment of Dry Eye Syndrome. J. Ocul. Pharmacol. Ther., 2017 Jun;33(5):375-382.
Kassem AA, Issa DA, Kotry GS, Farid RM., Thiolated alginate-based multiple layer mucoadhesive films of metformin for intra-pocket local delivery: in vitro characterization and clinical assessment. Drug Dev. Ind. Pharm. 2017 Jan;43(1):120-131.

Bioreducible?[edit]

The section below was removed for discussion because it is entirely primary lab research, and highly speculative, i.e., not encyclopedic per WP:PRIMARY. --Zefr (talk) 21:47, 13 February 2018 (UTC)[reply]

Bioreducible properties of thiolated polymers were first shown by Kataoka and co-workers ^[1] and in the following confirmed by numerous research groups such as by Lin et al. ^[2] or Schmitz et al. ^[3]. Due to these properties a targeted drug release under reducing conditions such as in the cytosol can be achieved ^[4]

References

^ Kakizawa, Y; Harada, A; Kataoka, K (1999). "Environment-sensitive stabilization of core–shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond". J Am Chem Soc. 121: 11247–11248.
^ Lin, C; Zhong, Z; Lok, MC; Jiang, X; Hennink, WE; Feijen, J; Engbersen, JF (2006). "Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties". J. Control. Release. 116 (2): 130–137.
^ Schmitz, T; Bravo-Osuna, I; Vauthier, C; Ponchel, G; Loretz, B; Bernkop-Schnürch, A (2007). "Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system". Biomaterials. 28 (3): 524–531.
^ Xu, J; Gattacceca, F; Amiji, M (2013). "Biodistribution and pharmacokinetics of EGFR-targeted thiolated gelatin nanoparticles following systemic administration in pancreatic tumor-bearing mice". Mol. Pharm. 10 (5): 2031–2044. doi:10.1021/mp400054e.

[1] Kakizawa, Y; Harada, A; Kataoka, K (1999). "Environment-sensitive stabilization of core–shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond". J Am Chem Soc. 121: 11247–11248.

[2] Lin, C; Zhong, Z; Lok, MC; Jiang, X; Hennink, WE; Feijen, J; Engbersen, JF (2006). "Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties". J. Control. Release. 116 (2): 130–137.

[3] Schmitz, T; Bravo-Osuna, I; Vauthier, C; Ponchel, G; Loretz, B; Bernkop-Schnürch, A (2007). "Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system". Biomaterials. 28 (3): 524–531.

[4] Xu, J; Gattacceca, F; Amiji, M (2013). "Biodistribution and pharmacokinetics of EGFR-targeted thiolated gelatin nanoparticles following systemic administration in pancreatic tumor-bearing mice". Mol. Pharm. 10 (5): 2031–2044. doi:10.1021/mp400054e.

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