User:Cayley P/sandbox

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[1]


Adding to an article exercise- Possible additions to cancer paragraph

My additions


COX- 2 appears to be related to cancers and abnormal growths in the intestinal tract. Overexpression of COX-2 produces excess prostaglandin E2, which has been shown to increase the possibility of colorectal cancer.[2] COX inhibitors have been shown to reduce the occurrence of cancers and pre-cancerous growths. The National Cancer Institute has done some studies on COX-2 and cancer. The FDA has approved Celebrex for treatment of familial adenomatous polyposis (FAP). COX-2 inhibitors are currently being studied in breast cancer and appear to be beneficial. (Current paragraph on page)

Reference Section[edit]

  1. ^ "COX-2 Protein Overview".
  2. ^ Greenhough, A.; Smartt, H. J.M.; Moore, A. E.; Roberts, H. R.; Williams, A. C.; Paraskeva, C.; Kaidi, A. (2009-01-09). "The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment". Carcinogenesis. 30 (3): 377–386. doi:10.1093/carcin/bgp014. ISSN 0143-3334.

Lipfert, Peter; Seitz, Ruediger; Arndt, Joachim O. (1987). "Studies of Local Anesthetic Action on Natural Spike Activity in the Aortic Nerve of Cats". Anesthesiology. Ovid Technologies (Wolters Kluwer Health). 66 (2): 210–213. doi:10.1097/00000542-198702000-00016. ISSN 0003-3022. PMID 3813081. Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs).

[1]

Cyclooxygenases: structural and functional insights (nih.gov)[1]

COX-2 Inhibitor 2[2]

  1. ^ Rouzer, Carol A.; Marnett, Lawrence J. (2009-4). "Cyclooxygenases: structural and functional insights". Journal of Lipid Research. 50 (Suppl): S29–S34. doi:10.1194/jlr.R800042-JLR200. ISSN 0022-2275. PMC 2674713. PMID 18952571. {{cite journal}}: Check date values in: |date= (help)CS1 maint: unflagged free DOI (link)
  2. ^ PubChem. "COX-2 Inhibitor II". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-03-12.