User:Crary033/sandbox/C6orf10
Uncharacterized protein C6orf10 is a protein that in humans is encoded by the C6orf10 gene.[1][2]C6orf10 is an open reading frame on chromosome 6 containing an uncharacterized protein with accession number NP_006772[3] . C6orf10 is also known as Testis Specific Basic Protein one (TSBP1) and Testis expressed basic protein one.[4] The location of the C6orf10 gene on chromosome 6 is 6p21.32 and its longest known mRNA transcript is 2,194 base pairs long[5][6]. Expression of this gene is highest in the testis but is also seen in other tissue types such as the brain, lens of the eye and the medulla[7][8][9]. The C6orf10 gene contains 9 different mRNAs with 8 alternatively spliced variants and one unspliced form. Also, four alternative polyadenylation sites have been identified[7]. The C6orf10 protein has three complete isoforms and five partial isoforms[3]. The longest isoform, which is isoform 1 contains 563 amino acids, and is 61495 kDa long.This protein is a part of the Neuromodulin-N superfamily[10]. The C6orf10 protein orthologs are restricted to mammals indicating an evolutionarily newer protein.
Gene[edit]
C6orf10 is located on chromosome 6 at 6p21.32
mRNA Transcript[edit]
Isoform 1 is the longest known transcript and is 2,194 bp long.
Protein[edit]
The longest protein encoded by C6orf10 is isoform 1 which is 563 amino acids long and contains a protein domain that is part of the Neuromodulin-N superfamily.
Homologs[edit]
Orthologs[edit]
Mammals
Primates: Northern White cheeked Gibbon (Nomascus leucogenys) Carnivora: Dog (Canis lupus familiaris), Cat (Felis catus)
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References[edit]
- ^ Stammers M, Rowen L, Rhodes D, Trowsdale J, Beck S (May 2000). "BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse". Immunogenetics. 51 (4–5): 373–82. doi:10.1007/s002510050633. PMID 10803852. S2CID 31938388.
- ^ "Entrez Gene: C6orf10 chromosome 6 open reading frame 10".
- ^ a b "testis-expressed basic protein 1 isoform a [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-25.
- ^ "TSBP1 Gene (protein coding)". www.genecards.org. Retrieved 2019-02-25.
- ^ "Homo sapiens testis expressed basic protein 1 (TSBP1), transcript variant 1, mRNA". 2018-11-11.
{{cite journal}}: Cite journal requires|journal=(help) - ^ "TSBP1 testis expressed basic protein 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-25.
- ^ a b "AceView: Gene:C6orf10, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2019-02-25.
- ^ "TSBP1 testis expressed basic protein 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-02-25.
- ^ "Tissue expression of C6orf10 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2019-02-25.
- ^ "NCBI CDD CDD Conserved Protein Domain Neuromodulin_N". www.ncbi.nlm.nih.gov. Retrieved 2019-02-25.
External links[edit]