User:Depalmal/Neurula project proposal

Content

The current Wikipedia article on the neurula defines what a neurula is, explains neurulation in a short paragraph, and contains a section regarding health consequences due to errors in neurulation.

To improve this page, we will expand upon the explanation of neurulation, adding specific details for a deeper understanding. This will include the stages of development of the neurula. However, we will not overdo this as there is already a Wikipedia page for neurulation.

The role of neurulation in the development of left/right asymmetry will be discussed.

The health/disease section will also be expanded upon. Neural tube defects will be discussed in general along with the more severe forms, including the briefly mentioned anencephaly NTD.

Current research regarding the neurula will also be provided.

References

Nishide K, Mugitani M, Kumano G, Nishida H. Neurula rotation determines left-right asymmetry in ascidian tadpole larvae. Development. 2012 Apr;139(8):1467-75. doi: 10.1242/dev.076083. Epub 2012 Mar 7.

Zhang Q, Xue P, Li H, Bao Y, Wu L, Chang S, Niu B, Yang F, Zhang T. Histone modification mapping in human brain reveals aberrant expression of histone H3 lysine 79 dimethylation in neural tube defects. Neurobiol Dis. 2013 Jan 29. pii: S0969-9961(13)00038-7. doi: 10.1016/j.nbd.2013.01.014.

Compagnon J, Heisenberg CP. Neurulation: coordinating cell polarisation and lumen formation. EMBO J. 2013 Jan 9;32(1):1-3. doi: 10.1038/emboj.2012.325. Epub 2012 Dec 4.

Ma P, Zhao S, Zeng W, Yang Q, Li C, Lv X, Zhou Q, Mao B. Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning. Biochem Biophys Res Commun. 2011 Aug 19;412(1):170-4. doi: 10.1016/j.bbrc.2011.07.068. Epub 2011 Jul 23.