User:Esimonelli/Rostral Migratory Stream

Project: Rostral Migratory Stream

Group Members: Alexandra Kennedy, Elizabeth Simonelli, Tyler Vandeventer, and John Westerdahl

Main Points

Definition

The rostral migratory stream (RMS) is a pathway along which developing neurons travel from the subventricular zone (SVZ) of the brain to the olfactory bulb. This a relatively long trip (several milimeters) for a cell measuring only 10-30 μm long. Once these cells reach the olfactory bulb they develop into interneurons. This pathway was originally found in rat brains but it has recently been discovered to exist in much larger brains including those of primates.

Types of Cells Involved

• A Cells
• B Cells
• C Cells
• Glial Cells

Migration Mechanics

• Speed of migration
• Proteins involved in scaffolding and cell adhesion molecules (NCAMs)
• Roles of microtubules in movement
• Cell signaling

Relevance

• Neurogenesis in adults
• Drug delivery into CNS
• Role in olfaction

References

1. Alvarez-Buylla, Arturo, et. al. (2002) Neurogenesis in Adult Subventricular Zone. The Journal of Neuroscience, (3): 629-634
2. Chazal, Geneviève, et. al. (2000) Consequences of Neural Cell Adhesion Molecule Deficiency on Cell Migration in the Rostral Migratory Stream of the Mouse. The Journal of Neuroscience, 20(4): 1446-1457
3. Scranton RA, Fletcher L, Sprague S, Jimenez DF, Digicaylioglu M (2011) The Rostral Migratory Stream Plays a Key Role in Intranasal Delivery of Drugs into the CNS. PLoS ONE 6(4): e18711. doi:10.1371/journal.pone.0018711