User:Fishgibblets/RecX

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RecX

RecX is a protein that negatively regulates RecA recombinase activity in a number of bacteria. The gene was originally identified as potentially regulating RecA activity in Pseudomonas aeruginosa because it is situated immediately downstream from RecA, and overexpression of RecA without RecX overexpression is toxic to P. aeruginosa, as well as Streptomyces lividans.^[1]

^ Sano, Y., "Role of the recA-related gene adjacent to the recA gene in Pseudomonas aeruginosa", J Bacteriol, 1993.

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^ Vierling, S.; Weber, T.; Wohlleben, W.; Muth, G., "Transcriptional and mutational analyses of the Streptomyces lividans recX gene and its interference with RecA activity", J Bacteriol, 2000.

The proteins being transcribed as part of an operon with RecA was first identified via qPCR in the Mycobacterium smegmatis^[1]

^ Papavinasasundaram, K. G.; Movahedzadeh, F.; Keer, J. T.; Stoker, N. G.; Colston, M. J.; Davis, E. O. "Mycobacterial recA is cotranscribed with a potential regulatory gene called recX", Mol Microbiol, 1997.

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[1] Sano, Y., "Role of the recA-related gene adjacent to the recA gene in Pseudomonas aeruginosa", J Bacteriol, 1993.

[2] Vierling, S.; Weber, T.; Wohlleben, W.; Muth, G., "Transcriptional and mutational analyses of the Streptomyces lividans recX gene and its interference with RecA activity", J Bacteriol, 2000.

[3] Papavinasasundaram, K. G.; Movahedzadeh, F.; Keer, J. T.; Stoker, N. G.; Colston, M. J.; Davis, E. O. "Mycobacterial recA is cotranscribed with a potential regulatory gene called recX", Mol Microbiol, 1997.

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