User:JaimeeDavis/TBR1

TBR1 Proposal

Definition

-T-box Brain Protein, TBR1 for short, also known as T-Brain 1, and TES-56

-made up of 6 exons

-transcription factor expressed in postmitotic projection neurons

-Classification Group: Beta-Hairpin-Ribbon-Group, Family: Transcription Factor T-Domain

Function

-developmental process

-normal brain development

-neuronal differentiation

-transition from intermediate progenitor cell to post mitotic neuron

-regulation of neurons in developing neocortex

History

-identified in 1995

Relation to Other Genes

-Human gene TBR1 has an orthologous gene in zebrafish

-TBR1 is downstream of Pax6

-TBR1 is a promoter of Auts2

-TBR1 represses Fezf2

-Af9 associates with transcriptional start site of TBR1

-TBR1 forms T-box gene family with TBR2 and T-BET

-CASK is a coactivator of TBR1

Experimentation/Studies in Other Species

-TBR1 is involved in frontal identity

-transcription factor sequence: Pax6 → Tbr2 → Tbr1

-Similar protein in mice involved in cortical development

-Expressed in mouse CNS

-Appears to be restricted to glutamatergic neurons in mice

References

Bedogni, Francesco et al. "Tbr1 Regulates Regional and Laminar Identity of Postmitotic Neurons in Developing Neocortex." PMC. 6 July 2010. Web. 27 Sept. 2011. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919950/?tool=pmcentrez>.

Büttner, Nicole et al. "Af9/Mllt3 Interferes with Tbr1 Expression through Epigenetic Modification of Histone H3K79 during Development of the Cerebral Cortex." PMC. 13 Apr. 2010. Web. 27 Sept. 2011. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872432/?tool=pmcentrez>.

Englund, C et al. "Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex." PMC. 5 Jan. 2005. Web. 27 Sept. 2011. <http://www.ncbi.nlm.nih.gov/pubmed/15634788>.

Han, Wenqi et al. "TBR1 Directly Represses Fezf2 to Control the Laminar Origin and Development of the Corticospinal Tract." PMC. 15 Feb. 2011. Web. 27 Sept. 2011. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041103/?tool=pmcentrez>.

Hevner, Robert et al. "Human TBR1." Wasserman Lab Online Tools. Transcription Factor Encyclopedia, 4 Aug. 2010. Web. 27 Sept. 2011. <http://www.cisreg.ca/cgi-bin/tfe/articles.pl?tfid=156>.

"Human Gene TBR1." UCSC Genome Browser Home. UniProt Consortium, 2009. Web. 27 Sept. 2011. <http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human>.

Division of Workload

We have decided to meet Tuesdays at 2 to work on our project. We think that this is the best way for all of us to discuss and understand fully the topic so that we can create a cohesive article. We recognize that we have not provided examples of current research. This is an area we plan to further develop as we go forth in this project.