User:Julialturner/BRCA1

BRCA1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD, 3PXE, 4IFI, 4IGK, 4JLU, 4OFB, 4U4A, 4Y18, 4Y2G
Identifiers
Aliases	BRCA1, breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated, BRCA1 DNA repair associated, Genes
External IDs	OMIM: 113705 HomoloGene: 5276 GeneCards: BRCA1
Genetically Related Diseases
	BRCA1 hereditary breast and ovarian cancer syndrome, breast carcinoma, urogenital neoplasm, ovarian neoplasm, hereditary breast ovarian cancer
Gene ontology
Molecular function	• tubulin binding; • metal ion binding; • enzyme binding; • zinc ion binding; • damaged DNA binding; • GO:0001948, GO:0016582 protein binding; • GO:0001105 transcription coactivator activity; • androgen receptor binding; • RNA binding; • ubiquitin protein ligase binding; • GO:0050372 ubiquitin-protein transferase activity; • DNA binding; • transferase activity; • RNA polymerase binding; • identical protein binding;
Cellular component	• BRCA1-BARD1 complex; • condensed nuclear chromosome; • BRCA1-A complex; • ubiquitin ligase complex; • plasma membrane; • nucleoplasm; • condensed chromosome; • cytoplasm; • chromosome; • nucleus; • lateral element; • GO:0009327 protein-containing complex; • ribonucleoprotein complex;
Biological process	• response to ionizing radiation; • centrosome cycle; • chromosome segregation; • protein K6-linked ubiquitination; • intrinsic apoptotic signaling pathway in response to DNA damage; • cell cycle; • double-strand break repair via nonhomologous end joining; • GO:0097285 apoptotic process; • regulation of apoptotic process; • regulation of gene expression by genetic imprinting; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of fatty acid biosynthetic process; • transcription, DNA-templated; • regulation of transcription by RNA polymerase III; • fatty acid biosynthetic process; • regulation of DNA methylation; • negative regulation of intracellular estrogen receptor signaling pathway; • protein autoubiquitination; • positive regulation of histone H3-K9 methylation; • DNA recombination; • positive regulation of angiogenesis; • response to estrogen; • cellular response to indole-3-methanol; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • GO:0045996 negative regulation of transcription, DNA-templated; • positive regulation of protein ubiquitination; • androgen receptor signaling pathway; • negative regulation of centriole replication; • postreplication repair; • lipid metabolism; • cellular response to tumor necrosis factor; • GO:1900404 positive regulation of DNA repair; • fatty acid metabolic process; • GO:1901313 positive regulation of gene expression; • negative regulation of histone H3-K4 methylation; • regulation of cell population proliferation; • negative regulation of reactive oxygen species metabolic process; • positive regulation of vascular endothelial growth factor production; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of histone H4-K20 methylation; • DNA double-strand break processing; • double-strand break repair via homologous recombination; • negative regulation of histone acetylation; • protein ubiquitination; • positive regulation of histone H3-K4 methylation; • GO:0100026 DNA repair; • double-strand break repair; • positive regulation of histone acetylation; • dosage compensation by inactivation of X chromosome; • negative regulation of histone H3-K9 methylation; • positive regulation of histone H3-K9 acetylation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • chordate embryonic development; • positive regulation of histone H4-K16 acetylation; • cellular response to DNA damage stimulus; • protein deubiquitination; • DNA replication; • mitotic G2/M transition checkpoint; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of G0 to G1 transition; • transcription by RNA polymerase II; • mitotic G2 DNA damage checkpoint signaling; • regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
RNA expression pattern
	; ;
	More reference expression data
Orthologs
	672
	n/a
	ENSG00000012048
	n/a
	P38398
	n/a
NM_007294; NM_007295; NM_007296; NM_007297; NM_007298;
	NM_007299; NM_007300; NM_007301; NM_007302; NM_007303; NM_007305; NM_007306
	n/a
	NP_009225; NP_009228; NP_009229; NP_009230; NP_009231
	n/a
	Wikidata
View/Edit Human

High traffic test case

Reference test[edit]

This is the text that you are going to verify with a reference.^[3]

References[edit]

^ "Diseases that are genetically associated with BRCA1 view/edit references on wikidata".
^ "Human PubMed Reference:".
^ Reference details go here

[1] "Diseases that are genetically associated with BRCA1 view/edit references on wikidata".

[2] "Human PubMed Reference:".

[3] Reference details go here

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