User:Littlefix21/sandbox
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| Names | |
|---|---|
| IUPAC name
(E)-10-Hydroxydec-2-enoic acid
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| Other names
10-Hydroxy-2-decenoic acid
Royal Jelly acid | |
| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChemSpider | |
| MeSH | C055543 |
PubChem CID
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| UNII | |
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| Properties | |
| C10H18O3 | |
| Molar mass | 186.251 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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The queen bee acid (10-hydroxy-2-decenoic acid) or 10-HDA is a bio-active compound found in royal jelly.[1][2][3][4]
Royal jelly is created in the hypopharyngeal and mandibular glands of the female worker bees' heads in order to feed the prospective queen larvae as well as feeding the queen herself.[5]
Royal jelly acid is being investigated for its pharmacological activities. Reports indicate that it promotes neurogenesis of neural stem/progenitor cells (cells capable of differentiating into neurons, astrocytes, or oligodendrocytes) in vitro and could provide an effective method to treat and prevent neurological disorders.[6]
In addition, royal jelly acid has been reported to have anti-tumor, anti-biotic, immunomodulatory, estrogenic, neurogenic, and innate immune response modulating activities.[7]
In the United States, the Food and Drug Administration has taken legal action against companies that have used unfounded claims of health benefits to market royal jelly products.[8][9]
Products from bees are considered to be a great source of nullifying the effects of oxidative stress underlying the pathogenesis of many diseases.[10] In diseases such as Parkinson's disease, the application of β-amyrin can aid in therapy.[10]
See also[edit]
Notes[edit]
References[edit][edit]
- ^ Bian, M. T. [Determination of 10-hydroxy-2-decenoic acid in ginseng royal jelly by reversed phase high performance liquid chromatography]. Chung Yao Tung Pao. 12(6):41-43, 1987.
- ^ Bloodworth, BC; Harn, CS; Hock, CT; Boon, YO (Jul–Aug 1995). "Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly" (PDF). Journal of AOAC International. 78 (4): 1019–23. doi:10.1093/jaoac/78.4.1019. PMID 7580313.
- ^ Genç, Mahmut; Aslan, Abdurrahman (1999). "Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography". Journal of Chromatography A. 839 (1–2): 265–268. doi:10.1016/S0021-9673(99)00151-X. PMID 10327631.
- ^ Ji, N; Yu, RG; Yang, QH; Yu, PH; Li, Y (Jul 1987). "[Determination of 10-hydroxy-trans-2-decenoic acid (10-HDA) in royal jelly by gas liquid chromatography]". Zhong Yao Tong Bao (Beijing, China : 1981). 12 (9): 28–31, 62. PMID 3449246.
- ^ Guendouz, Malika; Haddi, Abir; Grar, Hadria; Kheroua, Omar; Saidi, Djamel; Kaddouri, Hanane (2017-01-01). "Preventive effects of royal jelly against anaphylactic response in a murine model of cow's milk allergy". Pharmaceutical Biology. 55 (1): 2145–2152. doi:10.1080/13880209.2017.1383487. ISSN 1388-0209.
- ^ Hattori, Noriko; Nomoto, Hiroshi; Fukumitsu, Hidefumi; Mishima, Satoshi; Furukawa, Shoei (2007-01-01). "Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro". Biomedical Research. 28 (5): 261–266. doi:10.2220/biomedres.28.261. PMID 18000339.
- ^ Sugiyama, Tsuyoshi; Takahashi, Keita; Mori, Hiroshi (2012). "Royal Jelly Acid, 10-Hydroxy-trans-2-Decenoic Acid, as a Modulator of the Innate Immune Responses". Endocrine, Metabolic & Immune Disorders-Drug Targets. 12 (4): 368–376. doi:10.2174/187153012803832530. PMID 23061418.
- ^ "Federal Government Seizes Dozens of Misbranded Drug Products: FDA warned company about making medical claims for bee-derived products". Food and Drug Administration. Apr 5, 2010.
- ^ "Inspections, Compliance, Enforcement, and Criminal Investigations: Beehive Botanicals, Inc". Food and Drug Administration. March 2, 2007.
- ^ a b Kocot, Joanna; Kiełczykowska, Małgorzata; Luchowska-Kocot, Dorota; Kurzepa, Jacek; Musik, Irena (2018). "Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application". Oxidative Medicine and Cellular Longevity. 2018: 1–29. doi:10.1155/2018/7074209. ISSN 1942-0900.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
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