User:Lovinne/sandbox

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HW for 9th week (3/7)

Peer review: nicotanimide, RNA pol II
- Look for...
  - Clarity
  - completeness of coverage
  - organization
  - media
  - linked words
  - redundancy
  - sources

Intentions for Edit of Phosphatase Article

I want to improve and expound upon the following aspects of the enzyme phosphatase:

Write a more detailed general description of the enzyme that addresses its general function, what class of enzymes it belongs to, and a brief overview of its roles in the body.
Explore the general catalytic mechanism of phosphatase.
Address significant aspects of physiological relevance
Write in greater detail about 3 major types of phosphatase, including definition, mechanism, and physiological relevance. Briefly discuss sub-classes.
- Protein phosphatase
  - Mechanism
  - Subtypes: Ser/Thr, His, metallo-dependent
  - Role in signal transduction cascades, protein regulation,
- Alkaline phosphatase
  - Mechanism
  - Roles in digestion, agriculture, cancer
- Alkaline phosphatase
  - Mechanism
  - Roles in intestinal homeostatis, liver/bone/kidney, and developmental biology
Briefly overview significant uses of phosphatase inhibitors in drugs

Preliminary Bibliography

Fundamentals of Biochemistry; Voet, Voet, and Pratt (ISBN 978-1-118-91840-1)^[1]
Direct determination of phosphatase activity from physiological substrates in cells (DOI: 10.1371/journal.pone.0120087).^[2]
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (DOI: 10.1126/scisignal.2004712)^[3]
Human HAD phosphatases: structure, mechanism, and roles in health and disease (DOI: 10.1111/j.1742-4658.2012.08633.x) ^[4]
How do inhibitory phosphatases work? (PMID 12431385)^[5]

Homework due 2/21:

Check out ChemDraw
Okay images: self-made, public domain, wikimedia commons, copyrighted w/ free license
First draft due next week; print hard copy for Dr. Tienson to annotate
Complete media training

Homework due 2/14:

Post proposed outline to talk page of phosphatase article.

Homework for next week:

By tomorrow, update class dashboard name to reflect chosen article.
By Tuesday, post first five sources of bibliography to user page. (copy DOI, insert)
- WP:REFB
- WP:CITE

Notes[edit]

^ G.,, Voet, Judith; W.,, Pratt, Charlotte. Fundamentals of biochemistry : life at the molecular level. ISBN 9781118918401. OCLC 910538334.{{cite book}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)
^ Ren, Zhongyuan; Do, Le Duy; Bechkoff, Géraldine; Mebarek, Saida; Keloglu, Nermin; Ahamada, Saandia; Meena, Saurabh; Magne, David; Pikula, Slawomir (2015-03-18). "Direct Determination of Phosphatase Activity from Physiological Substrates in Cells". PLOS ONE. 10 (3): e0120087. doi:10.1371/journal.pone.0120087. ISSN 1932-6203. PMC 4364917. PMID 25785438.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
^ Couzens, Amber L.; Knight, James D. R.; Kean, Michelle J.; Teo, Guoci; Weiss, Alexander; Dunham, Wade H.; Lin, Zhen-Yuan; Bagshaw, Richard D.; Sicheri, Frank (2013-11-19). "Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions". Science Signaling. 6 (302): rs15. doi:10.1126/scisignal.2004712.
^ Seifried, Annegrit; Schultz, Jörg; Gohla, Antje (2013-01-01). "Human HAD phosphatases: structure, mechanism, and roles in health and disease". FEBS Journal. 280 (2): 549–571. doi:10.1111/j.1742-4658.2012.08633.x. ISSN 1742-4658.
^ Coggeshall, K. M.; Nakamura, Koji; Phee, Hyewon (2002-12-01). "How do inhibitory phosphatases work?". Molecular Immunology. 39 (9): 521–529. ISSN 0161-5890. PMID 12431385.

[1] G.,, Voet, Judith; W.,, Pratt, Charlotte. Fundamentals of biochemistry : life at the molecular level. ISBN 9781118918401. OCLC 910538334.{{cite book}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)

[2] Ren, Zhongyuan; Do, Le Duy; Bechkoff, Géraldine; Mebarek, Saida; Keloglu, Nermin; Ahamada, Saandia; Meena, Saurabh; Magne, David; Pikula, Slawomir (2015-03-18). "Direct Determination of Phosphatase Activity from Physiological Substrates in Cells". PLOS ONE. 10 (3): e0120087. doi:10.1371/journal.pone.0120087. ISSN 1932-6203. PMC 4364917. PMID 25785438.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

[3] Couzens, Amber L.; Knight, James D. R.; Kean, Michelle J.; Teo, Guoci; Weiss, Alexander; Dunham, Wade H.; Lin, Zhen-Yuan; Bagshaw, Richard D.; Sicheri, Frank (2013-11-19). "Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions". Science Signaling. 6 (302): rs15. doi:10.1126/scisignal.2004712.

[4] Seifried, Annegrit; Schultz, Jörg; Gohla, Antje (2013-01-01). "Human HAD phosphatases: structure, mechanism, and roles in health and disease". FEBS Journal. 280 (2): 549–571. doi:10.1111/j.1742-4658.2012.08633.x. ISSN 1742-4658.

[5] Coggeshall, K. M.; Nakamura, Koji; Phee, Hyewon (2002-12-01). "How do inhibitory phosphatases work?". Molecular Immunology. 39 (9): 521–529. ISSN 0161-5890. PMID 12431385.

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