User:Mr. Ibrahem/Atogepant

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Mr. Ibrahem/Atogepant
Clinical data
Trade namesQulipta
Other namesAGN-241689, MK-8031
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth
Drug classGepant[1]
Legal status
Legal status
Identifiers
  • (3S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide
Chemical and physical data
FormulaC29H23F6N5O3
Molar mass603.525 g·mol−1
3D model (JSmol)
  • C[C@@H]1[C@H](c2c(F)ccc(F)c2F)C[C@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)N1CC(F)(F)F
  • InChI=1S/C29H23F6N5O3/c1-13-16(22-18(30)4-5-19(31)23(22)32)8-20(26(42)40(13)12-29(33,34)35)38-25(41)15-7-14-9-28(10-21(14)37-11-15)17-3-2-6-36-24(17)39-27(28)43/h2-7,11,13,16,20H,8-10,12H2,1H3,(H,38,41)(H,36,39,43)/t13-,16-,20+,28+/m1/s1
  • Key:QIVUCLWGARAQIO-OLIXTKCUSA-N

Atogepant, sold under the brand name Qulipta, is a medication used to prevent migraines.[2] It is taken by mouth once per day.[2] Its use dose not appear to result in medication overuse headaches.[3]

Commons side effects include nausea, constipation, and tiredness.[2] Use in pregnancy may harm the baby.[2] It should not be taken by people with significant liver problems.[2] It is a calcitonin gene-related peptide receptor (CGRPR) antagonist, specifically a gepant.[2][1]

Atogepant was approved for medical use in the United States in 2021.[2] As of 2022 it is not approved in either Europe or the United Kingdom.[4] In the United States it costs about 1,000 USD per month.[5]

References[edit]

  1. ^ a b Tepper, Deborah (May 2020). "Gepants". Headache: The Journal of Head and Face Pain. 60 (5): 1037–1039. doi:10.1111/head.13791.
  2. ^ a b c d e f g h i j "Qulipta- atogepant tablet". DailyMed. Archived from the original on 1 November 2021. Retrieved 31 October 2021.
  3. ^ "Atogepant Monograph for Professionals". Drugs.com. Retrieved 27 October 2022.
  4. ^ "Atogepant". SPS - Specialist Pharmacy Service. 5 October 2017. Archived from the original on 7 December 2021. Retrieved 27 October 2022.
  5. ^ "Qulipta". Archived from the original on 27 October 2022. Retrieved 27 October 2022.
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