User:Mr. Ibrahem/Brompheniramine

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Mr. Ibrahem/Brompheniramine
Clinical data
Trade namesBromfed, Dimetapp, Bromfenex, and others
AHFS/Drugs.comMonograph
MedlinePlusa682545
Routes of
administration		By mouth
Drug classAntihistamine[1]
Legal status
Legal status
  • AU: S4 / S3 / S2
  • US: Rx-only / OTC
  • Unscheduled, OTC[2]
Pharmacokinetic data
MetabolismLiver
Elimination half-life24.9 ± 9.3 hours[3]
Duration of action48 hrs[1]
ExcretionUrine
Identifiers
  • (R/S)-3-(4-Bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
Chemical and physical data
FormulaC16H19BrN2
Molar mass319.246 g·mol−1
3D model (JSmol)
  • Brc1ccc(cc1)C(c2ncccc2)CCN(C)C
  • InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 checkY
  • Key:ZDIGNSYAACHWNL-UHFFFAOYSA-N checkY
  (verify)

Brompheniramine, sold under the brand name Dimetapp among others,[2] is an antihistamine used for symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.[1] Its use in children under 6 is not recommended.[4] It is taken by mouth.[1] Maximal effects occur around 6 hours and may may last for up to two days.[1]

Common side effects include sleepiness, restlessness, confusion, dry mouth, and blurred vision.[1] Other side effects may include urinary retention and seizures.[1] It is a first-generation antihistamine.[1]

Brompheniramine was patented in 1948 and came into medical use in 1955.[5] It is frequently sold in combination with other medications such as dextromethorphan, guaifenesin, or pseudoephedrine.[1] These combinations are available as generic medication and are relatively inexpensive.[6][7]

References[edit]

  1. ^ a b c d e f g h i j k "Brompheniramine Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 17 July 2021.
  2. ^ a b "Brompheniramine Uses, Side Effects & Warnings". Drugs.com. Archived from the original on 28 January 2021. Retrieved 25 March 2021.
  3. ^ Simons FE, Frith EM, Simons KJ (December 1982). "The pharmacokinetics and antihistaminic effects of brompheniramine". The Journal of Allergy and Clinical Immunology. 70 (6): 458–64. doi:10.1016/0091-6749(82)90009-4. PMID 6128358.
  4. ^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 312. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  5. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495. Archived from the original on 2021-05-12. Retrieved 2020-12-15.
  6. ^ "Brompheniramine / Dextromethorphan / Pseudoephedrine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 17 May 2020. Retrieved 17 July 2021.
  7. ^ "Compare Dimetapp Prices". GoodRx. Archived from the original on 3 November 2016. Retrieved 25 March 2021.
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