User:Mr. Ibrahem/Chronic traumatic encephalopathy

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Chronic traumatic encephalopathy
Other namesTraumatic encephalopathy syndrome, dementia pugilistica,[1] punch drunk syndrome
A normal brain (left) and one with CTE (right)
SpecialtyNeurology, psychiatry, sports medicine
SymptomsBehavioral problems, mood problems, problems with thinking[1]
ComplicationsDementia,[2] aggression, depression, suicidal thoughts[3]
Usual onsetYears after initial injuries[2]
CausesRepeated head injuries[1]
Risk factorsContact sports, military, domestic abuse, repeated banging of the head[1]
Diagnostic methodAutopsy[1]
Differential diagnosisAlzheimer's disease, Parkinson's disease[3]
TreatmentSupportive care[3]
FrequencyUncertain[2]

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repeated head injuries.[1] Symptoms do not typically begin until years after the injuries and can include behavioral problems, mood problems, and problems with thinking.[1][2] The disease often gets worse over time and can result in dementia.[2] It is unclear if the risk of suicide is altered.[1]

Most documented cases have occurred in athletes involved in contact sports such as boxing, American football, professional wrestling, ice hockey, rugby, and association football (soccer).[1][4] Other risk factors include being in the military, prior domestic violence, and repeated banging of the head.[1] The exact amount of trauma required for the condition to occur is unknown, and definitive diagnosis can only occur at autopsy.[1] The disease is classified as a tauopathy.[1]

There is no specific treatment for the disease.[3] Rates of CTE have been found to be about 30% among those with a history of multiple head injuries,[1] however population rates are unclear.[2] Research in brain damage as a result of repeated head injuries began in the 1920s, at which time the condition was known as dementia pugilistica or "punch drunk syndrome".[1][3] It has been proposed that the rules of some sports be changed as a means of prevention.[1]

References[edit]

  1. ^ a b c d e f g h i j k l m n o Asken, BM; Sullan, MJ; DeKosky, ST; Jaffee, MS; Bauer, RM (1 October 2017). "Research Gaps and Controversies in Chronic Traumatic Encephalopathy: A Review". JAMA Neurology. 74 (10): 1255–1262. doi:10.1001/jamaneurol.2017.2396. PMID 28975240.
  2. ^ a b c d e f Stein, TD; Alvarez, VE; McKee, AC (2014). "Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel". Alzheimer's Research & Therapy. 6 (1): 4. doi:10.1186/alzrt234. PMC 3979082. PMID 24423082.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  3. ^ a b c d e "Alzheimer's & Dementia". Alzheimer's Association. alz.org. Archived from the original on 17 May 2018. Retrieved 21 September 2017.
  4. ^ Maroon, Joseph C; Winkelman, Robert; Bost, Jeffrey; Amos, Austin C; Mathyssek, Christina; Miele, Vincent (2015). "Chronic Traumatic Encephalopathy in Contact Sports: A Systematic Review of All Reported Pathological Cases". PLOS One. 10 (2): e0117338. Bibcode:2015PLoSO..1017338M. doi:10.1371/journal.pone.0117338. PMC 4324991. PMID 25671598.{{cite journal}}: CS1 maint: unflagged free DOI (link)