User:Mr. Ibrahem/Clevidipine

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Mr. Ibrahem/Clevidipine
Clinical data
Trade namesCleviprex
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intravenous
Drug classCalcium channel blocker (dihydropyridine)[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability100% (used only IV)
Protein binding>99.5%
MetabolismBlood and tissue esterases
Onset of actionWith 4 min[1]
Elimination half-life1 minute
Duration of actionUp to 15 min[1]
ExcretionUrine (63–74%), feces (7–22%)
Identifiers
  • (RS)-5-O-(Butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Chemical and physical data
FormulaC21H23Cl2NO6
Molar mass456.32 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • O=C(OCOC(=O)CCC)\C1=C(\N/C(=C(/C(=O)OC)[C@H]1c2cccc(Cl)c2Cl)C)C

Clevidipine, sold under the brand name Cleviprex, is a medication used to treat high blood pressure.[1] This includes in hypertensive emergencies and around the time of surgery.[1] It is used by injection into a vein.[1] Effects begin within 4 minutes and last for up to 15 minutes.[1]

Common side effects include headache and nausea.[3] Other side effects may include low blood pressure, fast heart rate, and worsened heart failure.[3] It should not be used in those allergic to eggs or soy.[3] There are concerns that use during pregnancy may harm the baby.[4] It is a calcium channel blocker of the dihydropyridine type.[1]

Clevidipine was approved for medical use in the United States in 2008.[1] It is also available in a number of European countries.[5] In the United States 50 mg costs about 160 USD as of 2022.[6]

References[edit]

  1. ^ a b c d e f g h i j "Clevidipine Monograph for Professionals". Drugs.com. Archived from the original on 10 June 2021. Retrieved 5 January 2022.
  2. ^ "Archive copy" (PDF). Archived (PDF) from the original on 2021-11-02. Retrieved 2021-10-31.{{cite web}}: CS1 maint: archived copy as title (link)
  3. ^ a b c d "DailyMed - CLEVIPREX- clevidipine emulsion". dailymed.nlm.nih.gov. Archived from the original on 2 March 2021. Retrieved 5 January 2022.
  4. ^ "Clevidipine (Cleviprex) Use During Pregnancy". Drugs.com. Archived from the original on 26 November 2020. Retrieved 5 January 2022.
  5. ^ "List of nationally authorised medicinal products" (PDF). Archived (PDF) from the original on 5 July 2019. Retrieved 5 January 2022.
  6. ^ "Cleviprex Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 18 January 2021. Retrieved 5 January 2022.
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