User:Mr. Ibrahem/Etanercept
Clinical data | |
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Trade names | Enbrel, Benepali, Erelzi, others |
Other names | Etanercept-szzs, etanercept-ykro |
AHFS/Drugs.com | Monograph |
MedlinePlus | a602013 |
License data |
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Pregnancy category |
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Routes of administration | Subcutaneous injection |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 58–76% (SC) |
Metabolism | Reticuloendothelial system (speculative) |
Elimination half-life | 70–132 hours |
Chemical and physical data | |
Formula | C2224H3475N621O698S36 |
Molar mass | 51235.07 g·mol−1 |
Etanercept, sold under the brand name Enbrel among others, is a medication used to treat autoimmune diseases including rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, plaque psoriasis, and ankylosing spondylitis.[2] It is given by injection under the skin.[3]
Common side effects include pain at the site of injection and infections.[2] Other side effects may include cancers, heart failure, demyelinating diseases, allergic reactions, and pancytopenia.[4] Safety in pregnancy is unclear.[4] It is a TNF inhibitor which blocks tumor necrosis factor (TNF).[2] It a monoclonal antibody made by recombinant DNA techniques.[2][4]
Etanercept was approved for medical use in the United States in 1998 and Europe in 2000.[4][2] It is on the World Health Organization's List of Essential Medicines as an alternative to adalimumab.[5] In the United Kingdom 4 weeks of medication costs the NHS about £715 as of 2021.[3] This amount in the United States costs about 5,700 USD.[6]
References[edit]
- ^ a b "Etanercept Use During Pregnancy". Drugs.com. 24 January 2020. Archived from the original on 20 January 2021. Retrieved 13 August 2020.
- ^ a b c d e f "Enbrel". Archived from the original on 12 November 2020. Retrieved 16 December 2021.
- ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1161. ISBN 978-0857114105.
- ^ a b c d "Etanercept Monograph for Professionals". Drugs.com. Archived from the original on 28 September 2021. Retrieved 16 December 2021.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Etanercept Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 11 January 2022. Retrieved 16 December 2021.