User:Mr. Ibrahem/Naldemedine

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Mr. Ibrahem/Naldemedine
Clinical data
Trade namesSymproic, Rizmoic
Other namesS-297,995
AHFS/Drugs.comMonograph
MedlinePlusa617031
License data
Routes of
administration		By mouth
Drug classPeripherally acting μ-opioid receptor antagonist[1]
Legal status
Legal status
Pharmacokinetic data
Protein binding93–94%
Metabolismprimarily CYP3A4
Elimination half-life11 hrs
ExcretionUrine, feces
Identifiers
  • 17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide
Chemical and physical data
FormulaC32H34N4O6
Molar mass570.646 g·mol−1
3D model (JSmol)
  • CC(C)(c1nc(no1)c2ccccc2)NC(=O)C3=C([C@H]4[C@@]56CCN([C@@H]([C@@]5(C3)O)Cc7c6c(c(cc7)O)O4)CC8CC8)O
  • InChI=1S/C32H34N4O6/c1-30(2,29-33-27(35-42-29)18-6-4-3-5-7-18)34-28(39)20-15-32(40)22-14-19-10-11-21(37)25-23(19)31(32,26(41-25)24(20)38)12-13-36(22)16-17-8-9-17/h3-7,10-11,17,22,26,37-38,40H,8-9,12-16H2,1-2H3,(H,34,39)/t22-,26+,31+,32-/m1/s1
  • Key:AXQACEQYCPKDMV-RZAWKFBISA-N

Naldemedine, sold under the brand name Symproic and Rizmoic, is a medication used to treat opioid-induced constipation in chronic non-cancer pain.[1] It may be used when laxatives are not effective.[2] It is taken by mouth.[1]

Common side effects include abdominal pain, nausea, and diarrhea.[1] Other side effects may include gastrointestinal perforation, allergic reactions, and opioid withdrawal.[1] Safety in pregnancy is unclear.[3] It is a peripherally acting μ-opioid receptor antagonist, which prevents opioids from binding to receptors in the gut.[1][2] It generally dose not affect pain management.[4]

Naldemedine was approved for medical use in the United States in 2017 and Europe in 2019.[1][2] In the United States it costs about 330 USD per month as of 2021.[5] In the United Kingdom this amount costs about £42.[4]

References[edit]

  1. ^ a b c d e f g h i j "Naldemedine Monograph for Professionals". Drugs.com. Archived from the original on 8 June 2021. Retrieved 11 November 2021.
  2. ^ a b c "Rizmoic". Archived from the original on 29 December 2019. Retrieved 11 November 2021.
  3. ^ "Naldemedine (Symproic) Use During Pregnancy". Drugs.com. Archived from the original on 27 October 2020. Retrieved 11 November 2021.
  4. ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 70. ISBN 978-0857114105.
  5. ^ "Symproic Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 15 November 2021. Retrieved 11 November 2021.
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