User:Mr. Ibrahem/Pexidartinib

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Mr. Ibrahem/Pexidartinib
Clinical data
Trade namesTuralio
Other namesPLX-3397
AHFS/Drugs.comMonograph
MedlinePlusa619050
License data
Routes of
administration		By mouth
Drug classKinase inhibitor[1]
Legal status
Legal status
Identifiers
  • 5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)-3-pyridinyl]methyl}-2-pyridinamine
Chemical and physical data
FormulaC20H15ClF3N5
Molar mass417.82 g·mol−1
3D model (JSmol)
  • ClC=1C=C2C(=NC1)NC=C2CC=2C=CC(=NC2)NCC=2C=NC(=CC2)C(F)(F)F
  • InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
  • Key:JGWRKYUXBBNENE-UHFFFAOYSA-N

Pexidartinib, sold under the brand name Turalio, is a medication used to treat tenosynovial giant cell tumor (TGCT).[1] It is used in cases which result in significant problems and cannot be treated by surgery.[1] It is taken by mouth.[1]

Common side effects include liver problems, loss of hair color, tiredness, low neutrophils, increased cholesterol, eye swelling, and rash.[2] The liver problems can result in death.[2] Use in pregnancy may harm the baby.[1] It is a kinase inhibitor and works by blocking colony-stimulating factor-1 receptor (CSF-1R).[1]

Pexidartinib was approved for medical use in the United States in 2019.[1] It was refused approval in Europe in 2020 due to minimal benefits and concerns regarding side effects.[3] It is not approved in the United Kingdom.[4] In the United States it costs about 21,200 USD per month.[5]

References[edit]

  1. ^ a b c d e f g h "Pexidartinib Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 27 October 2021.
  2. ^ a b c "DailyMed - TURALIO- pexidartinib capsule". dailymed.nlm.nih.gov. Archived from the original on 24 October 2020. Retrieved 27 October 2021.
  3. ^ "Turalio". Archived from the original on 27 October 2021. Retrieved 27 October 2021.
  4. ^ "Pexidartinib". SPS - Specialist Pharmacy Service. 12 January 2016. Archived from the original on 27 October 2021. Retrieved 27 October 2021.
  5. ^ "Turalio Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 16 January 2021. Retrieved 27 October 2021.
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