User:Mr. Ibrahem/Pimozide
Clinical data | |
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Trade names | Orap |
AHFS/Drugs.com | Monograph |
MedlinePlus | a686018 |
License data | |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Typical antipsychotic |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 40-50% |
Metabolism | CYP3A4, CYP1A2 and CYP2D6 |
Elimination half-life | 55 hours (adults), 66 hours (children) |
Excretion | Urine |
Identifiers | |
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Chemical and physical data | |
Formula | C28H29F2N3O |
Molar mass | 461.557 g·mol−1 |
3D model (JSmol) | |
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Pimozide, sold under the brand name Orap among others, is a medication used to treat schizophrenia and Tourette syndrome.[1][2] In Tourette's it is used when other treatments such as haloperidol are not effective.[2] It is taken by mouth.[2]
Common side effects include parkinsonism, dry mouth, and sleepiness.[2] Other side effects may include tardive dyskinesia, neuroleptic malignant syndrome, QT prolongation, and seizures.[2] It is an antipsychotic in the diphenylbutylpiperidine class.[2] It affects both dopamine and serotonin receptors.[3]
Pimozide was patented in 1963 and came into medical use in France in 1969.[3] In the United Kingdom 100 tablets of 4 mg costs the NHS about £40 as of 2021.[1] In the United States this amount costs about 430 USD.[4]
References[edit]
- ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 408. ISBN 978-0857114105.
- ^ a b c d e f g h "Pimozide Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2021. Retrieved 28 October 2021.
- ^ a b Buschmann, Helmut; Holenz, Jörg; Párraga, Antonio; Torrens, Antoni; Vela, José Miguel; Díaz, José Luis (16 April 2007). Antidepressants, Antipsychotics, Anxiolytics, 2 Volume Set: From Chemistry and Pharmacology to Clinical Application. John Wiley & Sons. p. 528. ISBN 978-3-527-31058-6. Archived from the original on 28 October 2021. Retrieved 28 October 2021.
- ^ "Pimozide Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 April 2021. Retrieved 28 October 2021.