User:Mr. Ibrahem/Selinexor

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Mr. Ibrahem/Selinexor
Skeletal formula of selinexor
Clinical data
Trade namesXpovio, Nexpovio
Other namesKPT-330
AHFS/Drugs.comMonograph
MedlinePlusa619044
License data
Pregnancy
category
  • Use should be avoided
Routes of
administration		By mouth
Drug classInhibitor of nuclear export[1]
Legal status
Legal status
Pharmacokinetic data
Protein binding95%
MetabolismLiver oxidation, glucuronidation, and conjugation, by CYP3A4, UGT and GST
Elimination half-life6–8 hours
Identifiers
  • (2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl}-N′-pyrazin-2-ylprop-2-enehydrazide
Chemical and physical data
FormulaC17H11F6N7O
Molar mass443.313 g·mol−1
3D model (JSmol)
  • C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F

Selinexor sold under the brand name Xpovio among others, is a medication used to treat multiple myeloma.[3] It is used in cases were at least 4 other treatments have been found ineffective.[3] It is taken by mouth together with dexamethasone.[3][1]

Common side effects include nausea, weight loss, diarrhea, tiredness, low platelets, low red blood cells, low white blood cells, and low sodium.[1] Other side effects may include syncope.[3] Use during pregnancy may harm the baby.[3] It is a inhibitor of nuclear export and works by blocking the action of exportin 1.[1]

Selinexor was approved for medical use in the United States in 2019 and Europe in 2021.[3][1] In the United States it costs about 24,000 USD every 4 weeks.[4] While approved in the United Kingdom, it is not available there as of 2021.[5]

References[edit]

  1. ^ a b c d e f g "Nexpovio EPAR". European Medicines Agency (EMA). 25 January 2021. Archived from the original on 2 June 2021. Retrieved 27 May 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  2. ^ "Xpovio- selinexor tablet, film coated". DailyMed. 19 August 2019. Archived from the original on 29 August 2021. Retrieved 20 November 2019.
  3. ^ a b c d e f g h "Selinexor Monograph for Professionals". Drugs.com. Archived from the original on 14 August 2020. Retrieved 12 October 2021.
  4. ^ "Xpovio Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 23 April 2021. Retrieved 12 October 2021.
  5. ^ "Selinexor". SPS - Specialist Pharmacy Service. 19 June 2017. Archived from the original on 13 October 2021. Retrieved 12 October 2021.
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