User:Mr. Ibrahem/Solriamfetol

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Mr. Ibrahem/Solriamfetol
Clinical data
Trade namesSunosi
Other namesSKL-N05, ADX-N05, ARL-N05, YKP10A, R228060, and JZP-110; (R)-2-amino-3-phenylpropylcarbamate hydrochloride
AHFS/Drugs.comMonograph
MedlinePlusa619040
License data
Routes of
administration		By mouth
Drug classNorepinephrine–dopamine reuptake inhibitor[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability~95%[1]
Protein binding13.3–19.4%[1]
MetabolismMinimal[1]
Elimination half-life~7.1 hours[1]
ExcretionUrine (95% unchanged)
Identifiers
  • (2R)-2-Amino-3-phenylpropyl carbamate
Chemical and physical data
FormulaC10H14N2O2
Molar mass194.234 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)C[C@H](COC(=O)N)N
  • InChI=1S/C10H14N2O2/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H2,12,13)/t9-/m1/s1
  • Key:UCTRAOBQFUDCSR-SECBINFHSA-N

Solriamfetol, sold under the brand name Sunosi, is a medication used to treat excessive sleepiness associated with narcolepsy and obstructive sleep apnea.[1] It is taken by mouth.[3]

Common side effects include headache, nausea, anxiety, and trouble sleeping.[1] Other side effects may include increased blood pressure and abuse.[3] It interacts with monoamine oxidase (MAO) inhibitors.[3] Safety in pregnancy and breastfeeding is unclear.[4] It is a norepinephrine–dopamine reuptake inhibitor (NDRI); though how it improves wakefulness is not entirely clear.[1][5]

Solriamfetol was approved for medical use in the United States in 2019 and Europe in 2020.[3][5] In the United States its costs about 690 USD per month as of 2021.[6] In the United States it is a Schedule IV controlled substance.[1]

References[edit]

  1. ^ a b c d e f g h i j k l "Sunosi- solriamfetol tablet, film coated". DailyMed. 16 October 2019. Archived from the original on 7 August 2020. Retrieved 24 November 2019.
  2. ^ "Sunosi EPAR". European Medicines Agency (EMA). 12 November 2019. Archived from the original on 8 November 2020. Retrieved 26 September 2020.
  3. ^ a b c d e "Solriamfetol Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 14 October 2021.
  4. ^ "Solriamfetol (Sunosi) Use During Pregnancy". Drugs.com. Archived from the original on 26 October 2020. Retrieved 14 October 2021.
  5. ^ a b "Sunosi". Archived from the original on 8 November 2020. Retrieved 14 October 2021.
  6. ^ "Sunosi Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 27 December 2021. Retrieved 14 October 2021.
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