User:Mr. Ibrahem/Temazepam
Clinical data | |
---|---|
Trade names | Restoril, Normison, Nortem, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a684003 |
License data | |
Pregnancy category |
|
Dependence liability | High[1] |
Routes of administration | By mouth |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 96% |
Metabolism | Liver |
Elimination half-life | 8–20 hours |
Excretion | Kidney |
Identifiers | |
| |
Chemical and physical data | |
Formula | C16H13ClN2O2 |
Molar mass | 300.74 g·mol−1 |
3D model (JSmol) | |
| |
| |
(what is this?) (verify) |
Temazepam, sold under the brand names Restoril among others, is a medication used to treat trouble sleeping.[3] Such use should generally be for less than ten days.[3] It is taken by mouth.[3] Effects generally begin within an hour and last for up to eight hours.[4]
Common side effects include sleepiness, anxiety, confusion, and dizziness.[3] Serious side effects may include hallucinations, abuse, anaphylaxis, and suicide.[3] Use is generally not recommended together with opioids.[3] If the dose is rapidly decreased withdrawal may occur.[3] Use during pregnancy or breastfeeding is not recommended.[5] Temazepam is an intermediate acting benzodiazepine and hypnotic.[3][4] It works by affecting GABA within the brain.[3]
Temazapam was patented in 1962 and came into medical use in 1969.[6] It is available as a generic medication.[7] A month supply in the United Kingdom costs the NHS about £1.40 as of 2019.[7] In the United States, the wholesale cost of this amount is about US$1.76.[8] In 2017, it was the 142nd most commonly prescribed medication in the United States, with more than four million prescriptions.[9][10]
References[edit]
- ^ "Temazepam". www.drugbank.ca. Archived from the original on 28 August 2019. Retrieved 26 June 2019.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 6 August 2020. Retrieved 8 September 2020.
- ^ a b c d e f g h i "Temazepam Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 29 December 2019. Retrieved 8 April 2019.
- ^ a b Collins, Shelly Rainforth; RN-BC, Shelly Rainforth Collins (2015). Pharmacology and the Nursing Process. Elsevier Health Sciences. p. 193. ISBN 9780323358286. Archived from the original on 2020-01-04. Retrieved 2019-04-08.
- ^ "Temazepam (Restoril) Use During Pregnancy". Drugs.com. Archived from the original on 29 August 2019. Retrieved 8 April 2019.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 537. ISBN 9783527607495. Archived from the original on 2020-01-02. Retrieved 2019-03-02.
- ^ a b British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 481. ISBN 9780857113382.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
- ^ "Temazepam - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.