User:Mr. Ibrahem/Tinidazole

Mr. Ibrahem/Tinidazole
Clinical data
Trade names	Fasigyn, Simplotan, Tindamax, others
AHFS/Drugs.com	Monograph
MedlinePlus	a604036
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Protein binding	12%
Metabolism	Liver (CYP3A4)
Elimination half-life	12–14 hours
Excretion	Urine (20–25%), faeces (12%)
Identifiers
	IUPAC name 1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole;
Chemical and physical data
Formula	C8H13N3O4S
Molar mass	247.27 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [O-][N+](=O)c1cnc(n1CCS(=O)(=O)CC)C;
	InChI InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3 ; Key:HJLSLZFTEKNLFI-UHFFFAOYSA-N ;
	(verify)

Tinidazole, sold under the brand name Tindamax among others, is a medication used to treat a number of infections including amebiasis, giardiasis, trichomoniasis, bacterial vaginosis, and nongonococcal urethritis.^[2] It is taken by mouth.^[2]

Common side effects include nausea, tiredness, and headaches.^[2] Other side effects may include brownish urine, peripheral neuropathy, and allergic reactions.^[1]^[2] Use is not recommended during the initial part of pregnancy.^[2] It is a member of the nitroimidazole class and is believed to work by affecting DNA.^[2]

Tinidazole was developed in 1969.^[3] It is on the World Health Organization's List of Essential Medicines.^[4] It is available as a generic medication.^[5] In the United Kingdom 16 tablets of 500 mg costs the NHS about £11 as of 2021.^[6] This amount in the United States costs about 35 USD.^[5]

References[edit]

^ ^a ^b ^c ^d "TINIDAZOLE oral - Essential drugs". medicalguidelines.msf.org. Archived from the original on 29 August 2021. Retrieved 25 August 2020.
^ ^a ^b ^c ^d ^e ^f "Tinidazole Monograph for Professionals". Drugs.com. Archived from the original on 16 April 2021. Retrieved 4 October 2021.
^ Greenwood, David (21 February 2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. OUP Oxford. p. 315. ISBN 978-0-19-953484-5. Archived from the original on 4 October 2021. Retrieved 4 October 2021.
^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
^ ^a ^b "Tinidazole Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 October 2021. Retrieved 4 October 2021.
^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 574. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[MSF2020-1] "TINIDAZOLE oral - Essential drugs". medicalguidelines.msf.org. Archived from the original on 29 August 2021. Retrieved 25 August 2020.

[AHFS2021-2] ^ ^a ^b ^c ^d ^e ^f "Tinidazole Monograph for Professionals". Drugs.com. Archived from the original on 16 April 2021. Retrieved 4 October 2021.

[3] Greenwood, David (21 February 2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. OUP Oxford. p. 315. ISBN 978-0-19-953484-5. Archived from the original on 4 October 2021. Retrieved 4 October 2021.

[WHO23rd-4] World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.

[GX2021-5] "Tinidazole Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 October 2021. Retrieved 4 October 2021.

[BNF80-6] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 574. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

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