User:Mr. Ibrahem/Trifarotene

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Mr. Ibrahem/Trifarotene
Clinical data
Trade namesAklief
Other namesCD5789
AHFS/Drugs.comMonograph
MedlinePlusa620004
License data
Pregnancy
category
  • AU: D[1]
  • Contraindicated
Routes of
administration		Topical
Drug classRetinoid[2]
Legal status
Legal status
Identifiers
  • 4-[3-(3-tert-Butyl-4-pyrrolidin-1-ylphenyl)-4-(2-hydroxyethoxy)phenyl]benzoic acid
Chemical and physical data
FormulaC29H33NO4
Molar mass459.586 g·mol−1
3D model (JSmol)
  • CC(C)(C)C1=C(C=CC(=C1)C2=C(C=CC(=C2)C3=CC=C(C=C3)C(=O)O)OCCO)N4CCCC4
  • InChI=1S/C29H33NO4/c1-29(2,3)25-19-23(10-12-26(25)30-14-4-5-15-30)24-18-22(11-13-27(24)34-17-16-31)20-6-8-21(9-7-20)28(32)33/h6-13,18-19,31H,4-5,14-17H2,1-3H3,(H,32,33)
  • Key:MFBCDACCJCDGBA-UHFFFAOYSA-N

Trifarotene, sold under the brand name Aklief, is a medication used for acne.[2] It is applied to the skin as a cream.[2] Moisturizer may also be used to help prevent irritation of the skin.[2]

Common side effects include itchiness, irritation, and easy sunburns.[2] There are concerns that use during pregnancy may harm the baby.[5] It is a retinoid; specifically a fourth generation selective retinoic acid receptor (RAR)-γ agonist.[2][6]

Trifarotene was approved for medical use in the United States, Canada, and Europe in 2019.[2][5] In the United States a 45 gram tube costs about 575 USD as of 2021.[7]

References[edit]

  1. ^ a b "Trifarotene Product Information". Therapeutic Goods Administration (TGA). Archived from the original on 23 May 2021. Retrieved 23 May 2021.
  2. ^ a b c d e f g h i "Trifarotene Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 19 September 2021.
  3. ^ "Archive copy" (PDF). Archived (PDF) from the original on 23 May 2021. Retrieved 26 June 2021.{{cite web}}: CS1 maint: archived copy as title (link)
  4. ^ "Aklief- trifarotene cream". DailyMed. Archived from the original on 23 May 2021. Retrieved 22 May 2021.
  5. ^ a b "Australian Public Assessment Report for Trifarotene" (PDF). Archived (PDF) from the original on 23 September 2021. Retrieved 19 September 2021.
  6. ^ Scott LJ (November 2019). "Trifarotene: First Approval". Drugs. 79 (17): 1905–1909. doi:10.1007/s40265-019-01218-6. PMID 31713811. S2CID 207964653. Archived from the original on 29 August 2021. Retrieved 26 June 2021.
  7. ^ "Aklief Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 September 2021.
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