User:Quaenuncabibis/Sebastian Maerkl

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Professor
Sebastian Josef Maerkl
Sebastian Josef Maerkl in 2015
Born1980 (age 43–44)
Munich, Germany
NationalityGermany
EducationBiology, chemistry
Alma materFairleigh Dickinson University, California Institute of Technology
Scientific career
InstitutionsEPFL (École Polytechnique Fédérale de Lausanne)
ThesisMicrofluidic Large-Scale Integration and its Application to Systems Biology (2008)
Doctoral advisorStephen Quake
Websitelbnc.epfl.ch


Sebastian Josef Maerkl (born 1980 in Munich, Germany) is a German XXX. He is a professor of XXX at EPFL (École Polytechnique Fédérale de Lausanne) and the head of the Laboratory of Biological Network Characterization.[1][2]

Career[edit]

In 2001, Maerkl received Bachelo's degrees in biology and in chemistry from Fairleigh Dickinson University. He then joined Stephen Quake at the Biophysics and Biochemistry Department at the California Institute of Technology and contributed to the early development of microfluidic technology. He graduated in the field of biotechnology with a PhD thesis on "Microfluidic Large-Scale Integration and its Application to Systems Biology."[3]

For this work he was awarded the Demetriades-Tsafka-Kokalis prize,[4] and the 1st place at the Innovator’s Challenge from Stanford University, University of California, Berkeley, and California Institute of Technology.[5]

In 2008, Maerkl joined the EPFL's Institute of Bioengineering and the School of Engineering first as an assistant professor and was promoted to associate professor with tenure in 2015. 

In 2012 and received the Prix SSV – Ambition for dedication to teaching and promotion of EPFL students and the school at large. Prof. Maerkl was awarded an ERC Consolidator Grant, an HFSP Program Grant, a SystemsX.ch RTD grant, a SNF Sinergia grant, and a SNF NRP 78 Covid-19 research grant amongst others. Prof. Maerkl published over 50 peer-reviewed publications and 6 patents, gave over 90 invited seminars, organised several international conferences and workshops, and serves as a reviewer for national and international funding agencies and journals. The lab hosted one Fulbright Scholar, two Whitaker and one Think Swiss Fellows. His lab is currently working at the interface of micro-engineering, systems biology, synthetic biology, and molecular diagnostics. Prof Maerkl started the EPFL iGEM team in 2008 and has been advising the teams from 2008 to 2020. During this period the EPFL teams won 8 Gold, 2 Silver, and 1 bronze medal and were awarded 5 prices. In 2019, the EPFL iGEM team became the Grand Prize Winner in the Overgrad category and the first Swiss team to have won the competition.

Research[edit]

Distinctions[edit]

2019 iGEM Grand Prize Winner https://2019.igem.org/Competition/Results https://en.wikipedia.org/wiki/International_Genetically_Engineered_Machine 2012 Prix SSV - Ambition 2008 Demetriades-Tsafka-Kokkalis Prize in Biotechnology or Related Fields https://www.demetriades.caltech.edu/winners.html

Selected works[edit]

  • Thorsen, T.; Maerkl, S. J.; Quake, S. R. (2002). "Microfluidic Large-Scale Integration". Science. 298 (5593): 580–584. Bibcode:2002Sci...298..580T. doi:10.1126/science.1076996. PMID 12351675. S2CID 6716278.
  • Maerkl, Sebastian J.; Quake, Stephen R. (2007). "A Systems Approach to Measuring the Binding Energy Landscapes of Transcription Factors" (PDF). Science. 315 (5809): 233–237. Bibcode:2007Sci...315..233M. doi:10.1126/science.1131007. PMID 17218526. S2CID 17045536.
  • Rajkumar, Arun S.; Dénervaud, Nicolas; Maerkl, Sebastian J. (2013). "Mapping the fine structure of a eukaryotic promoter input-output function". Nature Genetics. 45 (10): 1207–1215. doi:10.1038/ng.2729. PMID 23955598. S2CID 18048208.
  • Denervaud, N.; Becker, J.; Delgado-Gonzalo, R.; Damay, P.; Rajkumar, A. S.; Unser, M.; Shore, D.; Naef, F.; Maerkl, S. J. (2013). "A chemostat array enables the spatio-temporal analysis of the yeast proteome". Proceedings of the National Academy of Sciences. 110 (39): 15842–15847. Bibcode:2013PNAS..11015842D. doi:10.1073/pnas.1308265110. PMC 3785771. PMID 24019481.
  • Niederholtmeyer, H.; Stepanova, V.; Maerkl, S. J. (2013). "Implementation of cell-free biological networks at steady state". Proceedings of the National Academy of Sciences. 110 (40): 15985–15990. Bibcode:2013PNAS..11015985N. doi:10.1073/pnas.1311166110. PMC 3791785. PMID 24043836.
  • Niederholtmeyer, Henrike; Sun, Zachary Z.; Hori, Yutaka; Yeung, Enoch; Verpoorte, Amanda; Murray, Richard M.; Maerkl, Sebastian J. (2015). "Rapid cell-free forward engineering of novel genetic ring oscillators". eLife. 4: e09771. doi:10.7554/eLife.09771. PMC 4714972. PMID 26430766.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Piraino, Francesco; Volpetti, Francesca; Watson, Craig; Maerkl, Sebastian J. (2016). "A Digital–Analog Microfluidic Platform for Patient-Centric Multiplexed Biomarker Diagnostics of Ultralow Volume Samples". ACS Nano. 10 (1): 1699–1710. doi:10.1021/acsnano.5b07939. PMID 26741022.
  • Swank, Zoe; Laohakunakorn, Nadanai; Maerkl, Sebastian J. (2019). "Cell-free gene-regulatory network engineering with synthetic transcription factors". Proceedings of the National Academy of Sciences. 116 (13): 5892–5901. doi:10.1073/pnas.1816591116. PMC 6442555. PMID 30850530.
  • Lavickova, Barbora; Maerkl, Sebastian J. (2019). "A Simple, Robust, and Low-Cost Method to Produce the PURE Cell-Free System". ACS Synthetic Biology. 8 (2): 455–462. doi:10.1021/acssynbio.8b00427. PMID 30632751.

References[edit]

  1. ^ "14 new professors at the two Federal Institutes of Technology | ETH-Board". www.ethrat.ch. Retrieved 2021-06-09.
  2. ^ "LBNC | Laboratory of Biological Network Characterization". lbnc.epfl.ch. Retrieved 2021-06-09.
  3. ^ Maerkl, Sebastian Josef (2008). Microfluidic Large Scale Integration and its Application to Systems Biology (phd thesis). California Institute of Technology.
  4. ^ "The Demetriades - Tsafka - Kokkalis Prize". demetriades.caltech.edu. Retrieved 2021-06-09.
  5. ^ "Prof Sebastian Maerkl". OpenPlant. Retrieved 2021-06-09.

External links[edit]

Category:XXXX births Category:Living people Category:UXXXX alumni Category:XXXX alumni Category:Academic staff of the École Polytechnique Fédérale de Lausanne Category:XXXX women scientists Category: XXXX Category: XXXX

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