User:Thatsomaven/draft proposal

This topic is being edited as an assignment in an undergraduate neurobiology course. The course is participating in the Wikipedia Education Program. The revised article will be posted by March 24, 2014.

Causes

Some of the causes of integrative agnosia include stroke, traumatic brain injury, Alzheimer's disease, an anoxic episode following myocardial infarction, and progressive multifocal leukoencephalopathy.

Symptoms

Symptoms generally include memory or learning impairments, with the inability to integrate parts coherently.

Diagnosis

Cases with integrative agnosia appear to have medial ventral lesions in the extrastriate cortex. Those who have integrative agnosia are better able to identify inanimate than animate items, which indicates processes that lead to accurate perceptual organization of visual information can be impaired. This is attributed to the importance of perceptual updating of stored visual knowledge, which is particularly important for classes of stimuli that have many perceptual neighbors and/or stimuli for which perceptual features are central to their stored representations. Patients also show a tendency to process visual stimuli initially at a global rather than local level. Although the grouping of local elements into perceptual wholes can be impaired, patients can remain sensitive to holistic visual representations.

Research

A case study on a patient named H.J.A. is discussed and analyzed by M. Jane Riddoch and Glyn W Humphreys. Because this case study is done specifically on the symptoms of one person diagnosed with integrative agnosia, generalizations cannot be made directly from the results and conclusions about the disease as a whole about those who are also diagnosed with this disease.

Like many people who are diagnosed with integrative agnosia, H.J.A. was diagnosed with this disease after suffering a stroke during a surgical procedure in an operating room. The patient underwent several experiments to verify the specific type of agnosia. H.J.A. showed top half visual deficits of the entire visual field in both right and left eyes. Lower visual fields showed normal patterns to the stimulus.

Through the first experiment, the patient showed that tactile presentation of an object helped H.J.A. significantly in identifying an object. When the object was presented only visually, the patient struggled and showed difficulty. Objects used were common everyday objects. The patient always used descriptive terminology to identify an object instead of a single word or term. However, H.J.A. showed an ability to copy objects and match two objects, both pictures and physical objects.

The second experiment showed that H.J.A. was able to identify figures better when presented the silhouette. Other patients with integrative agnosia also tend to show this symptom. The patient lacks local information of the figures to support the global information, which explains the lack of confidence in naming the object. H.J.A. also shows trouble discriminating figures that are significant and others that are meaningless stimuli. This, in turn, can explain why the patient cannot distinguish overlapping figures.

The third experiment showed that the patient was able to give important information about an object, even though, previously, could not identify the object visually. The memory of the patient is intact despite visual deficits. In the fourth and final section of experiments, the patient shows a lack of visual color knowledge, but structures of a given specific object is not impaired, as H.J.A. uses the technique of drawing from memories. This shows that the patient’s visual perceptions and memories containing prior knowledge are not altered by integrative agnosia following the stroke.

In a second case study also performed by the M. Jane Riddock and Glyn W. Humphreys, H.J.A was the subject case study to determine the effects Integrative Agnosia has on visual and spatial short-term memory.

In the first group of experiments, Riddick and Humphreys tested the patient's visual, spatial, and perceptual capabilities. They first had him draw his bedroom by vision, and comparing it to his drawing from memory at a specific date. They repeated this again again one year later. His results showed that patients with Integrative Agnotia have difficulties recalling spatial information from long-term memory. This was also echoed the patients inability to assess spatial locations of cities he was familiar with before his stroke, showing his spatial ability impairment.

When H.J.A was asked to compare images of human faces, he proved to be able to point out specific facial features. However this experiment showed that the patient was unable to make side by side comparisons suggesting that patients with Integrative Agnosia are unable to integrate the features into a perceptual representation. To contrast, the patient did well when asked to determine the angle of hands of a clock, an inanimate object. But because the patient had to simply make a global judgment based on the hands of the clock, there were not any judgments based on the perception of local parts.

In the second group of experiments, the patient was tested with manipulation of an image, spatial memory, and pattern tasks.
The patient performed a series of tasks such as the Moscovitch Letter Manipulation Task, the Brooks Matrix Task, and a Compass Directions Task. The patient proved able to receive the spatial material well with short-term memory when manipulating materials without a reference frame. The patients was still able to make global processes, identify shapes, single lines, and letters, but lacked the ability to process configurations in perceptual representations, in the respective tasks. When visually holding an image for a minimal 10 seconds, the patient was able to process a spatial pattern and transfer that image onto paper accurately. The experiments have showed that where the parts specifically fail to integrate, is when the patent's perception on spatial elements are introduced to a point of reference, as opposed to without a reference frame.

In the last set of experiments, the patient is being tested on reproduction of visual stimuli and reproduction of possible and impossible figures. The date suggested that the patient had an ability again maintain the global information in order to draw items, and reiterated his difficulty in maintaining local elements and spatial relations in a reference frame. The last experiment (experiment 11) was the most difficult for H.J.A visually. He was significantly impaired in drawing the impossible figures provided and spent a significant amount of time more than the control elderly population used in this experiment processing the information to be able to transform them on paper. The patient demonstrated a lack of representation of all local parts when reproducing the image.

It was concluded that tasks performed well included the tasks involving ranges of imagery-based tasks, accurately make judgments about global representations such as the angles of a clock, maintained visual patters over inter-stimulus intervals, mentally rotating letters, manipulating 2 elements of an image. In contrast, impairment was gauged to be the lack of the ability in recalling spatial layouts, judging spacial directions, judging relative positions of objects, The Brooks Matrix Test, Compass Direction Task, reproducing abstract patterns, and reproducing both possible and impossible figures. Due to the impairment, it was identified that the patient did not have intact imagery and visual short-term memory, made apparent by the spacial relations test. Due to Integrative Agnotia, the patients take information from a top-down manner, using stored knowledge to retrieve an objects perceptual properties. It is much more difficult for patients to use a bottom-up method, or perceiving through a visual stimulus, because of the inability to accurately code the patterns in the visual short-term memory.

Treatment

One treatment thought to be effective is the repeated exposure to a particular face or object, where impaired perception may be reorganized in memory, leading to improvement on tests of imagery relative to tests of perception.

Assessing Integrative Agnosia

When determining whether a patient has form agnosia or integrative agnosia, an Efron shape test can be performed. A poor score on the Efron shape test will indicate form agnosia, as apposed to integrative agnosia. A good score on the Efron shape test, but a poor score on a figure-ground segmentation test and an overlapping figures test will indicate integrative agnosia. A patient will integrative agnosia will find it hard to group and segment shapes, especially if there are overlapping animate items or they can over segment objects with high internal detail. However, the patient should have a understand basic coding of shape.