User:Vlaize/sandbox/Osteotoxicity

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Osteotoxicity
Damage to the bone (osteo-) by drugs, chemicals or any other compounds resulting in impaired bone formation, mineralization and remodeling.
In vitro cell systems such as osteosarcoma cell lines (HOS TE 85 and ROS 17.28) were used to evidence the osteotoxicity of cadmium and lead.^[1] Fish, in particular zebrafish, have been used as in vivo systems to assess osteotoxicity and study underlying mechanisms.^[2]

References[edit]

^ Angle CR, Thomas DJ, Swanson SA (1993) Osteotoxicity of cadmium and lead in HOS TE 85 and ROS 17/2.8 cells: Relation to metallothionein induction and mitochondrial binding. BioMetals 5:179–184
^ Fernández I, Gavaia P, Laizé V, Cancela ML (2018) Fish as a model to assess chemical toxicity in bone. Aquatic Toxicology 194:208-226

[1] Angle CR, Thomas DJ, Swanson SA (1993) Osteotoxicity of cadmium and lead in HOS TE 85 and ROS 17/2.8 cells: Relation to metallothionein induction and mitochondrial binding. BioMetals 5:179–184

[2] Fernández I, Gavaia P, Laizé V, Cancela ML (2018) Fish as a model to assess chemical toxicity in bone. Aquatic Toxicology 194:208-226

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