User talk:Developmentalbio

Paracrine signalling is a type of cell-cell communication in which the target cell is nearby the sending cell.

The jak-stat signaling pathway utilizes a phosphorylated tyrosine kinase activity to activate the Janus kinase which activates STATS. This signal eventually reached the nucleus to regulate gene expression.

The hedgehog signaling pathway utilizes the hedgehog ligand which binds to patched. This in turn releases patched's inhibition of smoothened, which initiates a signal transduction pathway.

Developmentalbio (talk) 03:25, 20 March 2013 (UTC)

<Cohen M.M. Jr. (2003) The hedgehog signaling network. Am J Med Genet, 123A:5-28.> [1]

<Darnell J.E. Jr , Kerr I.M., Stark G.R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415–21>[2]

<Jiang, J. & Hui, C.C. (2008) Hedgehog signaling in development and cancer. Dev. Cell 15, 801–812.>[3]

<Hooper, J. E. & Scott, M. P. (2005) Communicating with Hedgehogs. Nature Rev. Mol. Cell Biol. 6, 306–317.>[4]

<Rawlings J.S., Rosler K.M., Harrison D.A. (2004) The JAK/STAT signaling pathway. J Cell Sci 117 : 1281 –1283>[5]

<Robbins D.J., Fei D.L., Riobo N.A. (2012) The hedgehog signal transduction network. Sci. Signal., p. re6>[6]

<Nybakken, K. & Perrimon, N. (2002) Hedgehog signal transduction: recent findings. Curr. Opin. Genet. Dev. 12, 503–511>[7]

<Schindler C & Darnell J.E. Jr . (1995) Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621–51>[8]

<Yu, H. & Jove, R. (2004) The STATs of cancer — new molecular targets come of age. Nature Rev. Cancer 4, 97–105.>[9]

Developmentalbio (talk) 02:54, 20 March 2013 (UTC)

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