Wikipedia:USEP/Courses/JHU MolBio Ogg FA13/Group 84B

Group 84B

This is a group page for the 410.602 Johns Hopkins Molecular Biology, section 84 course. This group will be working on the article TBD.

Use the talk page here to collaborate as a group, when learning to use and navigate Wikipedia, assessing articles, or for any other topic.

Use this page (not the talk page) for article assessments; rationale for selecting an article; etc (as specified in the milestone summary chart.

Please create a new section here for each of those assignments.

Initial article assessments from Adimart1

Gene Silencing

From what I can see, the page desperately needs inline citations. It has a references and a list of studiessection but there are no footnotes indicating which references are regarding which study and some of the studies have no references as all. I also feel that the subject could be vastly expanded up for clarity and completeness. Here are some links for possible references: http://www.ncbi.nlm.nih.gov/pubmed/24021962 and http://www.ncbi.nlm.nih.gov/pubmed/23351378

Transferase

Also basically a stub. Needs extensive expansion to adequately cover the topic. Also, an expanded bibliography and inline citations. Possible references: http://www.ncbi.nlm.nih.gov/pubmed/23345616 and http://www.ncbi.nlm.nih.gov/pubmed/22956494

Initial article assessment from WillPugarth

Histone acetylation and deacetylation

This article has a generic image (of an acetyl group) which does not seem to really bring together the concepts illustrated in the text. It includes some citations, however the second half of the article is severely lacking in evidence; the citations included seem to be paraphrases, and others portions make assertions that are not necessarily common knowledge. Some in-text links to other articles for clarification could be added. Additionally, the entire article consists of a single section, which probably ignores the proposed MCB Style Guide.

Possible Sources: http://www.ncbi.nlm.nih.gov/pubmed/24092806, http://www.ncbi.nlm.nih.gov/pubmed/24081331, http://www.ncbi.nlm.nih.gov/pubmed/24068969, http://www.sciencemag.org/content/336/6087/1445.abstract

Acetyltransferase

This article seems like it is merely a bunch of links to examples. The image included doesn’t explain what the enzyme does. Honestly this article doesn’t have very much work completed on it yet. The method of action for acetyltransferase needs to be added. Explanatory text also is a must.

Possible Sources: http://www.ncbi.nlm.nih.gov/pubmed/17380162, http://web.williams.edu/imput/synapse/pages/IA3.html, http://onesci.com/journals/science_journal_97.pdf

Rationale for article choice

Transferase

As our first choice, gene silencing, had already been chosen by another group, we chose the Transferase article because both of us were interested in the action and biochemistry of this family of enzymes. Also, transferases are extremely important in many biological functions, so they definitely deserve a larger and more complete entry than the stub currently in place. While the topic Acetyltransferase may have been related, the scope available for Transferase should prove much more accessible and have a wider breadth of sources available for improving its quality.

Furthermore, the stub fails to address the history of discovery of important transferases, mechanisms by which important transferases act, as well as control methods for transferases. These additions can add some much needed depth and breadth to the article, as it currently is woefully lacking in ancillary data. Another necessary addition is the improvement of diagrams and imagery relating to transferase action. These images are necessary for improved understanding by visitors to the page. And without modifications such as those mentioned here, large amounts of information is being left out. Lastly, references must be improved and expanded as the article is changed. This, along with increased linking to other Wikipedia articles, will also improve the quality of this stub.

Unit 8 Progress Report

• We have added two new sections to the article: "Transferase Deficiencies" and "History."
• Added new Wikipedia cross reference links to other articles
• Added prose
• Added/Revised "See also" heading
• Added/Revised "References" heading

Unit 10 Progress Report

Completed:

• Added new section on biotechnology applications
• Combined and eliminated a section, put into Transferase reactions section
• Improved wikilinking, improved syntax, content edits, new citations
• Changed History section to be per decade
• Added equation to Donor/Acceptor in Transferase reactions section (Thanks Jim892!)
• Added images

Next:

• Need to add more images and diagrams
• Add equations for each of the EC system transferases listed
• Add nomenclature example for systematic naming
• Tables?
• Improve headings to be more informative
• Add Terminal transferases to Biotech section
• Find diagrams for some of the reactions listed (or make them)
• Add Discovery of RNAP (RNA Polymerase) to history section?
• Add Kinetics Section . . . Found sources for Kinetics Section (as per outline in sandbox). Will need to add section on CoA Transferase in E.coli. (this is as per suggestions from several reviewers! Thanks everybody!)--WillPugarth (talk) 05:50, 16 November 2013 (UTC)

Unit 14 Update

Completed since last update:

• Added EC Reactions, Deficiencies, and Histo blood group sections; expanded history section
• Added diagrams and images, equations for each reaction type
• Improved citations
• Made all changes (as far as I can tell) suggested by Neelix in previous review (includes removing duplicate wikilinks, heading fixes, removal of category links, captions added)
• Attempted to address all changes suggested by others

Next/In progress:

• Add section on mechanisms, regulation, and thermodynamics
• Describe cofactors/add cofactors section
• Structure: similarities between Transferases and Hydrolases

Overall changes to Transferase Article:

• Extensive content additions
• Improvements to references
• Improved wikilinking
• Addition of images and diagrams.
• Created table for EC classification
• Overall Wikipedia guideline fixes

Special thanks to (in no particular order): Neelix (main Wikipedia editor), Adimart1 (group partner), Agulati4, Galemu2, Jim892, Pdholak1, Hnagy2, Madscientist2007, T.Shafee (Evo&Evo), jirwin1097, Juanquina Thomas, Wenwatata, and countless others who did quick fixes here and there throughout the project. Thanks everybody!--WillPugarth (talk) 23:03, 14 December 2013 (UTC)