YEATS domain

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	4tmp, 3fk3, 3rls, 2l7e, 3qrl

YEATS domain
YEATS domain
Identifiers
Symbol	YEATS
Pfam	PF03366
InterPro	IPR005033
PROSITE	PS51037
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	4tmp, 3fk3, 3rls, 2l7e, 3qrl

In molecular biology, the YEATS domain is a protein domain found in a variety of proteins from eukaryotic organisms.^[1] YEATS domain proteins are found in a variety of chromatin modification molecular complexes. Structurally the domain has an immunoglobulin like fold.^[2] The YEATS domain has shown to bind to acetyllysine protein modifications.^[3] In addition to lysine acetylation, the YEATS domain has shown to be a reader domain for various lysine acylations, with highest affinity for lysine crotonylation.^[4] ^[5]

References[edit]

^ Schulze JM, Wang AY, Kobor MS (2009). "YEATS domain proteins: a diverse family with many links to chromatin modification and transcription". Biochem. Cell Biol. 87 (1): 65–75. doi:10.1139/O08-111. PMID 19234524.
^ Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS (2009). "Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation". Proc. Natl. Acad. Sci. U.S.A. 106 (51): 21573–8. doi:10.1073/pnas.0906539106. PMC 2799888. PMID 19966225.
^ Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SY, Li W, Li H, Shi X (2014). "AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation". Cell. 159 (3): 558–71. doi:10.1016/j.cell.2014.09.049. PMC 4344132. PMID 25417107.
^ Li Y, Sabari BR, Panchenko T, Wen H, Zhao D, Guan H, Wan L, Huang H, Tang Z, Zhao Y, Roeder RG, Shi X, Allis CD, Li H (2016). "Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain". Molecular Cell. 62 (2): 181–193. doi:10.1016/j.molcel.2016.03.028. PMC 4841940. PMID 27105114.
^ Andrews FH, Shinsky SA, Shanle EK, Bridgers JB, Gest A, Tsun IK, Krajewski K, Shi X, Strahl BD, Kutateladze TG (2016). "The Taf14 YEATS domain is a reader of histone crotonylation". Nat. Chem. Biol. 12 (6): 396–8. doi:10.1038/nchembio.2065. PMC 4871749. PMID 27089029.

[pmid19234524-1] Schulze JM, Wang AY, Kobor MS (2009). "YEATS domain proteins: a diverse family with many links to chromatin modification and transcription". Biochem. Cell Biol. 87 (1): 65–75. doi:10.1139/O08-111. PMID 19234524.

[pmid19966225-2] Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS (2009). "Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation". Proc. Natl. Acad. Sci. U.S.A. 106 (51): 21573–8. doi:10.1073/pnas.0906539106. PMC 2799888. PMID 19966225.

[pmid25417107-3] Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SY, Li W, Li H, Shi X (2014). "AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation". Cell. 159 (3): 558–71. doi:10.1016/j.cell.2014.09.049. PMC 4344132. PMID 25417107.

[pmid27105114-4] Li Y, Sabari BR, Panchenko T, Wen H, Zhao D, Guan H, Wan L, Huang H, Tang Z, Zhao Y, Roeder RG, Shi X, Allis CD, Li H (2016). "Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain". Molecular Cell. 62 (2): 181–193. doi:10.1016/j.molcel.2016.03.028. PMC 4841940. PMID 27105114.

[pmid27089029-5] Andrews FH, Shinsky SA, Shanle EK, Bridgers JB, Gest A, Tsun IK, Krajewski K, Shi X, Strahl BD, Kutateladze TG (2016). "The Taf14 YEATS domain is a reader of histone crotonylation". Nat. Chem. Biol. 12 (6): 396–8. doi:10.1038/nchembio.2065. PMC 4871749. PMID 27089029.

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[2]

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[5]

See also[edit]

References[edit]