Ying E. Zhang
Ying E. Zhang | |
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| Alma mater | Peking University (BS, MS) University of Wisconsin–Madison (PhD) |
| Scientific career | |
| Fields | Biochemistry, cancer biology |
| Institutions | National Cancer Institute |
| Thesis | Insights into mechanisms of F1F0ATP synthase by genetic analysis of subunit C from Escherichia coli (1995) |
| Doctoral advisor | Robert H. Fillingame |
Ying E. Zhang is a Chinese-American biochemist specialized in TGF-beta signaling and functions of ubiquitin E3 ligase Smurfs to better understand cancer cells and metastasis. She is a senior investigator in the Laboratory of Cellular and Molecular Biology at the National Cancer Institute.
Education[edit]
Zhang received her B.S. degree in chemistry and M.S. degree in biochemistry from Peking University. She obtained her Ph.D. degree from University of Wisconsin–Madison in 1995.[1][2] Her dissertation was titled, Insights into mechanisms of F1F0ATP synthase by genetic analysis of subunit C from Escherichia coli. Zhang's doctoral advisor was Robert H. Fillingame.[3] She completed her postdoctoral training with Rik Derynck in University of California, San Francisco.[1][2]
Career and research[edit]
Zhang joined the National Cancer Institute's (NCI) Laboratory of Cellular and Molecular Biology in 2000 as a tenure-track investigator and became a senior investigator in 2007.[1][2]
Zhang's research focuses on understanding TGF-beta signaling and functions of ubiquitin E3 ligase Smurfs. She identified and characterized several key molecules in the TGF-beta signaling pathway, including Smads and Smurfs. Discoveries from her group generated mechanistic insight into how TGF-beta controls cellular responses through Smad-dependent and -independent pathways in normal and cancer cells. On the front of Smurf E3 ligases, their findings extended the function of Smurfs beyond TGF-beta pathway to genome stability and metastasis.[1] In 2020, she was elected Fellow of the American Institute for Medical and Biological Engineering.[4] She was elected a Fellow of the American Association for the Advancement of Science in 2021.[5]
References[edit]
- ^ a b c d "Ying E. Zhang, Ph.D." Center for Cancer Research. 2014-08-12. Retrieved 2020-10-11.
This article incorporates text from this source, which is in the public domain.
- ^ a b c "Principal Investigators". NIH Intramural Research Program. Retrieved 2020-10-11. This article incorporates text from this source, which is in the public domain.
- ^ Zhang, Ying (1995). Insights into mechanisms of F1F0ATP synthase by genetic analysis of subunit C from Escherichia coli. OCLC 620713432.
- ^ "Ying E. Zhang, Ph.D. COF-5148 - AIMBE". Retrieved 2020-10-11.
- ^ "Six NIH'ers Elected 2021 AAAS Fellows". NIH Record. 2022-02-18. Retrieved 2022-10-09.
This article incorporates public domain material from websites or documents of the National Institutes of Health.| Authority control databases: Academics |
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- Living people
- Peking University alumni
- University of Wisconsin–Madison alumni
- National Institutes of Health people
- American people of Chinese descent
- People's Republic of China emigrants to the United States
- American women biochemists
- Chinese biochemists
- 21st-century American women scientists
- 21st-century Chinese scientists
- Fellows of the American Institute for Medical and Biological Engineering
- 21st-century American biologists
- 21st-century American chemists
- Chinese women biologists
- Chinese women chemists
- American medical researchers
- Chinese medical researchers
- Women medical researchers
- Cancer researchers
- Fellows of the American Academy of Arts and Sciences