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16S rRNA (cytidine1409-2'-O)-methyltransferase

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16S rRNA (cytidine1409-2'-O)-methyltransferase
Identifiers
EC no.2.1.1.227
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

16S rRNA (cytidine1409-2'-O)-methyltransferase (EC 2.1.1.227, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytidine1409-2'-O)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine1409 in 16S rRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA

The bifunctional enzyme from Mycobacterium tuberculosis.

References

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  1. ^ Johansen SK, Maus CE, Plikaytis BB, Douthwaite S (July 2006). "Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs". Molecular Cell. 23 (2): 173–82. doi:10.1016/j.molcel.2006.05.044. PMID 16857584.
  2. ^ Maus CE, Plikaytis BB, Shinnick TM (February 2005). "Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis". Antimicrobial Agents and Chemotherapy. 49 (2): 571–7. doi:10.1128/AAC.49.2.571-577.2005. PMC 547314. PMID 15673735.
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