FSU beat its first five opponents by an average score of 46–3, during which linebacker Derrick Brooks outscored all five opponents combined. The Seminoles' first real contest didn't come until October 9, when the third ranked Miami Hurricanes came to Tallahassee with a 31-game regular season win streak. That game was sealed when FSU safety Devin Bush picked off a Frank Costa pass and ran it back 40 yards for a Florida State touchdown, making the score 28–10 with 4:59 to play.
On November 13, 1993, Florida State played Notre Dame in a matchup of unbeaten teams. FSU was ranked #1 and Notre Dame was ranked #2. In a matchup hailed as the "Game of the Century", the Seminoles bid for a perfect season fell short as Notre Dame prevailed, 31–24. The Irish had leads of 24–7 and 31–17 before the Seminoles scored late (on a pass tipped in the end zone) to cut the final margin to seven points. After that game, Notre Dame was voted #1 and FSU was voted #2.
However, #1 Notre Dame lost at home the following week to #17 Boston College 41–39 on a 41-yard field goal as time expired. The voters returned the Seminoles to the #1 spot, and they were matched against Nebraska (now #2) in the Orange Bowl. Florida State rallied late to eke out an 18–16 win, as Nebraska missed a potential game-winning 45-yard field goal on the game's final play. After the bowl games, 12–1 Florida State was voted #1 and 11–1 Notre Dame was voted #2 in both polls.