2-Oxohistidine
Appearance
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Names | |
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IUPAC name
3-(2-Oxo-2H-imidazol-4-yl)alanine
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Identifiers | |
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C6H7N3O3 | |
Molar mass | 169.140 g·mol−1 |
Appearance | white solid |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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2-Oxohistidine is a derivative of histidine damaged by reactive oxygen species. It is a biological marker for assessing protein modifications from oxidative stress.[1] In particular, it arises by iron-catalyzed reaction with hydrogen peroxide.[2]
References
[edit]- ^ Uchida K, Kawakishi S (1993). "2-Oxo-histidine as a novel biological marker for oxidatively modified proteins". FEBS Lett. 332 (3): 208–210. Bibcode:1993FEBSL.332..208U. doi:10.1016/0014-5793(93)80632-5. PMID 8405458.
- ^ Lee, Jin-Won; Helmann, John D. (2006). "The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation". Nature. 440 (7082): 363–367. doi:10.1038/nature04537. PMID 16541078.