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2-dehydro-3-deoxygluconokinase

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2-dehydro-3-deoxygluconokinase
2-Keto-3-deoxygluconate kinase homohexamer, Thermus thermophilus
Identifiers
EC no.2.7.1.45
CAS no.9026-54-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) is an enzyme that catalyzes the chemical reaction

ATP + 2-dehydro-3-deoxy-D-gluconate ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Thus, the two substrates of this enzyme are ATP and 2-dehydro-3-deoxy-D-gluconate, whereas its two products are ADP and 6-phospho-2-dehydro-3-deoxy-D-gluconate.[1]

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase. Other names in common use include 2-keto-3-deoxygluconokinase, 2-keto-3-deoxy-D-gluconic acid kinase, 2-keto-3-deoxygluconokinase (phosphorylating), 2-keto-3-deoxygluconate kinase, and ketodeoxygluconokinase. This enzyme participates in pentose phosphate pathway and pentose and glucuronate interconversions.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1WYE.

References

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  1. ^ Cynkin MA, Ashwell G (June 1960). "Uronic acid metabolism in bacteria. IV. Purification and properties of 2-keto-3-deoxy-D-gluconokinase in Escherichia coli". The Journal of Biological Chemistry. 235 (6): 1576–9. doi:10.1016/S0021-9258(19)76843-4. PMID 13813474.